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Lemieszek M, Rzeski W. Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class. Contemp Oncol (Pozn). 2012;16(4):285-9doi: 10.5114/wo.2012.30055.
Lemieszek, M., & Rzeski, W. (2012). Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class. Contemporary oncology (Poznan, Poland), 16(4), 285-9. https://doi.org/10.5114/wo.2012.30055
Lemieszek, Marta, and Rzeski, Wojciech. "Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class." Contemporary oncology (Poznan, Poland) vol. 16,4 (2012): 285-9. doi: https://doi.org/10.5114/wo.2012.30055
Lemieszek M, Rzeski W. Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class. Contemp Oncol (Pozn). 2012;16(4):285-9. doi: 10.5114/wo.2012.30055. Epub 2012 Sep 29. PMID: 23788896; PMCID: PMC3687424.
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Contemp Oncol (Pozn). 2012;16(4):285-9. doi: 10.5114/wo.2012.30055. Epub 2012 Sep 29.

Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class.

Contemporary oncology (Poznan, Poland)

Marta Lemieszek, Wojciech Rzeski

Affiliations

  1. Department of Medical Biology, Institute of Agricultural Medicine, Lublin, Poland.

PMID: 23788896 PMCID: PMC3687424 DOI: 10.5114/wo.2012.30055

Abstract

Basidiomycete mushrooms represent a valuable source of biologically active compounds with anticancer properties. This feature is primarily attributed to polysaccharides and their derivatives. The anticancer potential of polysaccharides is linked to their origin, composition and chemical structure, solubility and method of isolation. Moreover, their activity can be significantly increased by chemical modifications. Anticancer effects of polysaccharides can be expressed indirectly (immunostimulation) or directly (cell proliferation inhibition and/or apoptosis induction). Among the wide range of polysaccharides with documented anticancer properties, lentinan, polysaccharide-K (PSK) and schizophyllan deserve special attention. These polysaccharides for many years have been successfully applied in cancer treatment and their mechanism of action is the best known.

Keywords: Basidiomycetes; Krestin; PSK; anticancer properties; lentinan; polysaccharides; schizophyllan

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