Display options
Cite
Fleming SM, Jordan MC, Mulligan CK, et al. Impaired baroreflex function in mice overexpressing alpha-synuclein. Front Neurol. 2013;4:103doi: 10.3389/fneur.2013.00103.
Fleming, S. M., Jordan, M. C., Mulligan, C. K., Masliah, E., Holden, J. G., Millard, R. W., Chesselet, M. F., & Roos, K. P. (2013). Impaired baroreflex function in mice overexpressing alpha-synuclein. Frontiers in neurology, 4103. https://doi.org/10.3389/fneur.2013.00103
Fleming, Sheila M, et al. "Impaired baroreflex function in mice overexpressing alpha-synuclein." Frontiers in neurology vol. 4 (2013): 103. doi: https://doi.org/10.3389/fneur.2013.00103
Fleming SM, Jordan MC, Mulligan CK, Masliah E, Holden JG, Millard RW, Chesselet MF, Roos KP. Impaired baroreflex function in mice overexpressing alpha-synuclein. Front Neurol. 2013 Jul 23;4:103. doi: 10.3389/fneur.2013.00103. eCollection 2013. PMID: 23888153; PMCID: PMC3719027.
Copy Download .nbib Format: NLM
Share it on

Front Neurol. 2013 Jul 23;4:103. doi: 10.3389/fneur.2013.00103. eCollection 2013.

Impaired baroreflex function in mice overexpressing alpha-synuclein.

Frontiers in neurology

Sheila M Fleming, Maria C Jordan, Caitlin K Mulligan, Eliezer Masliah, John G Holden, Ronald W Millard, Marie-Françoise Chesselet, Kenneth P Roos

Affiliations

  1. Department of Psychology, University of Cincinnati , Cincinnati, OH , USA ; Department of Neurology, University of Cincinnati , Cincinnati, OH , USA.

PMID: 23888153 PMCID: PMC3719027 DOI: 10.3389/fneur.2013.00103

Abstract

Cardiovascular autonomic dysfunction, such as orthostatic hypotension consequent to baroreflex failure and cardiac sympathetic denervation, is frequently observed in the synucleinopathy Parkinson's disease (PD). In the present study, the baroreceptor reflex was assessed in mice overexpressing human wildtype alpha-synuclein (Thy1-aSyn), a genetic mouse model of synucleinopathy. The beat-to-beat change in heart rate (HR), computed from R-R interval, in relation to blood pressure was measured in anesthetized and conscious mice equipped with arterial blood pressure telemetry transducers during transient bouts of hypertension and hypotension. Compared to wildtype, tachycardia following nitroprusside-induced hypotension was significantly reduced in Thy1-aSyn mice. Thy1-aSyn mice also showed an abnormal cardiovascular response (i.e., diminished tachycardia) to muscarinic blockade with atropine. We conclude that Thy1-aSyn mice have impaired basal and dynamic range of sympathetic and parasympathetic-mediated changes in HR and will be a useful model for long-term study of cardiovascular autonomic dysfunction associated with PD.

Keywords: Parkinson’s disease; alpha-synuclein; baroreflex; mouse model; orthostatic hypotension

References

  1. Neurosci Lett. 1995 Apr 28;190(1):17-20 - PubMed
  2. Ann N Y Acad Sci. 2001 Jun;940:469-87 - PubMed
  3. Clin Res Cardiol. 2010 Nov;99(11):701-6 - PubMed
  4. Lancet Neurol. 2003 Nov;2(11):669-76 - PubMed
  5. Neurogastroenterol Motil. 2012 Sep;24(9):e425-36 - PubMed
  6. J Neurosci Res. 2011 Jul;89(7):1091-102 - PubMed
  7. J Neurosci Res. 2002 Jun 1;68(5):568-78 - PubMed
  8. Hypertension. 2005 Dec;46(6):1333-9 - PubMed
  9. Neurobiol Dis. 2012 Jun;46(3):572-80 - PubMed
  10. Hum Mol Genet. 2010 May 1;19(9):1633-50 - PubMed
  11. Circ Res. 2002 Mar 8;90(4):458-64 - PubMed
  12. Auton Neurosci. 2007 Oct 30;136(1-2):82-9 - PubMed
  13. Neurobiol Aging. 2013 Mar;34(3):928-35 - PubMed
  14. Cleve Clin J Med. 2009 Apr;76 Suppl 2:S47-50 - PubMed
  15. Neurology. 2004 Sep 28;63(6):1093-5 - PubMed
  16. Mol Genet Metab. 2005 Sep-Oct;86(1-2):233-43 - PubMed
  17. Neuroscience. 2006 Nov 3;142(4):1245-53 - PubMed
  18. Neurobiol Aging. 2001 May-Jun;22(3):435-8 - PubMed
  19. Clin Auton Res. 2006 Feb;16(1):46-54 - PubMed
  20. Neuroreport. 2008 May 28;19(8):873-6 - PubMed
  21. Acta Neuropathol. 1976 Mar 30;34(3):183-97 - PubMed
  22. Clin Auton Res. 2007 Apr;17(2):118-21 - PubMed
  23. Mov Disord. 2010 Oct 30;25(14):2296-303 - PubMed
  24. J Card Fail. 2010 Sep;16(9):786-96 - PubMed
  25. Neurology. 1999 Apr 12;52(6):1269-71 - PubMed
  26. Neurobiol Aging. 2003 Mar-Apr;24(2):197-211 - PubMed
  27. Brain. 2004 Apr;127(Pt 4):768-72 - PubMed
  28. Eur J Neurosci. 2008 Jul;28(2):247-56 - PubMed
  29. Eur J Neurosci. 2012 Mar;35(6):870-82 - PubMed
  30. Clin Auton Res. 2007 Apr;17(2):93-8 - PubMed
  31. Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H964-72 - PubMed
  32. Mol Cell Neurosci. 2011 Mar;46(3):597-606 - PubMed
  33. Am J Physiol Endocrinol Metab. 2000 Oct;279(4):E886-92 - PubMed
  34. Brain Res Bull. 1993;31(6):737-44 - PubMed
  35. PLoS Curr. 2011 Nov 04;3:RRN1266 - PubMed
  36. Hypertension. 2007 Jan;49(1):120-6 - PubMed
  37. J Neurol Sci. 2007 Dec 15;263(1-2):133-8 - PubMed
  38. Neurobiol Dis. 2012 Aug;47(2):258-67 - PubMed
  39. Am J Physiol Heart Circ Physiol. 2000 Aug;279(2):H733-40 - PubMed
  40. J Nucl Med. 2000 Jan;41(1):71-7 - PubMed
  41. Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R3-R12 - PubMed
  42. Synapse. 2007 Dec;61(12):991-1001 - PubMed

Publication Types

Grant support