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Sommer BR, Mitchell EL, Wroolie TE. Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity. Ther Adv Neurol Disord. 2013;6(4):211-27doi: 10.1177/1756285613481257.
Sommer, B. R., Mitchell, E. L., & Wroolie, T. E. (2013). Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity. Therapeutic advances in neurological disorders, 6(4), 211-27. https://doi.org/10.1177/1756285613481257
Sommer, Barbara R, et al. "Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity." Therapeutic advances in neurological disorders vol. 6,4 (2013): 211-27. doi: https://doi.org/10.1177/1756285613481257
Sommer BR, Mitchell EL, Wroolie TE. Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity. Ther Adv Neurol Disord. 2013 Jul;6(4):211-27. doi: 10.1177/1756285613481257. PMID: 23858325; PMCID: PMC3707352.
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Ther Adv Neurol Disord. 2013 Jul;6(4):211-27. doi: 10.1177/1756285613481257.

Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity.

Therapeutic advances in neurological disorders

Barbara R Sommer, Erica L Mitchell, Tonita E Wroolie

Affiliations

  1. Stanford University School of Medicine, Department of Psychiatry, 401 Quarry Road, Stanford, CA 94305-5723, USA.

PMID: 23858325 PMCID: PMC3707352 DOI: 10.1177/1756285613481257

Abstract

This paper reviews the clinical implications of topiramate (TPM)-induced cognitive deficits in patients with epilepsy, migraine headache, obesity, and in normal populations, followed by reviews of the literature describing the reversal of such deficits upon medication discontinuation. It also discusses animal investigations of TPM's role of neuroprotection in brain injury. TPM's most intolerable adverse effects (AEs) are on verbal fluency and reaction time, resulting in high discontinuation rates in patients taking it for epilepsy and migraine headache. However, because TPM is so effective in the treatment of epilepsy and migraine headache, its use is expected to continue. There appears to be greater tolerance of TPM's cognitive AEs when it is used in the treatment of obesity, perhaps because of the lower doses required. Research attempting to predict the populations most vulnerable to the cognitive effects caused by TPM is ongoing. Studies suggest that one such population may include patients with a past psychiatric history. Slow titration and administration of the lowest possible doses may decrease risk of cognitive deficits.

Keywords: cognition; epilepsy; migraine; obesity; psychiatric; topiramate

References

  1. Clin Pharmacol Ther. 2009 Mar;85(3):283-8 - PubMed
  2. Epilepsy Behav. 2004 Jun;5(3):380-7 - PubMed
  3. Brain Res. 2005 Oct 5;1058(1-2):129-36 - PubMed
  4. Epilepsy Behav. 2009 Jan;14(1):40-7 - PubMed
  5. Epilepsy Res. 2002 Oct;51(3):217-32 - PubMed
  6. Clin Neuropharmacol. 2001 Sep-Oct;24(5):284-9 - PubMed
  7. Epilepsy Behav. 2012 May;24(1):74-80 - PubMed
  8. Neurology. 2003 May 13;60(9):1483-8 - PubMed
  9. Neurology. 2003 Apr 8;60(7):1104-7 - PubMed
  10. Epilepsia. 2000;41(S1):3-9 - PubMed
  11. Int J Obes (Lond). 2013 Jun;37(6):889-91 - PubMed
  12. Exp Neurol. 2006 Oct;201(2):470-8 - PubMed
  13. Epilepsy Behav. 2006 Jun;8(4):736-41 - PubMed
  14. Neurosci Lett. 2000 Mar 10;281(2-3):183-6 - PubMed
  15. Psychiatry Clin Neurosci. 2012 Apr;66(3):235-41 - PubMed
  16. Headache. 2005 Apr;45 Suppl 1:S66-73 - PubMed
  17. Lancet. 2011 Apr 16;377(9774):1341-52 - PubMed
  18. Arch Neurol. 2004 Apr;61(4):490-5 - PubMed
  19. Epilepsy Behav. 2005 Jun;6(4):529-36 - PubMed
  20. Int J Obes Relat Metab Disord. 2004 Nov;28(11):1399-410 - PubMed
  21. J Affect Disord. 2005 Aug;87(2-3):243-52 - PubMed
  22. J Anal Toxicol. 2006 Oct;30(8):599-602 - PubMed
  23. J Clin Psychopharmacol. 2002 Dec;22(6):599-609 - PubMed
  24. CNS Drugs. 2001;15(5):339-50 - PubMed
  25. J Neurol Neurosurg Psychiatry. 1999 Jul;67(1):44-50 - PubMed
  26. Epilepsia. 2003 Mar;44(3):339-47 - PubMed
  27. Obes Rev. 2005 Feb;6(1):5-7 - PubMed
  28. Obes Res. 2004 Oct;12(10):1658-69 - PubMed
  29. J Neurol. 2004 Aug;251(8):943-50 - PubMed
  30. J Clin Psychopharmacol. 2003 Oct;23(5):500-4 - PubMed
  31. Seizure. 2005 Sep;14(6):396-402 - PubMed
  32. Pediatr Neurol. 2010 Mar;42(3):187-95 - PubMed
  33. Seizure. 2002 Jun;11(4):255-60 - PubMed
  34. J Clin Psychopharmacol. 2002 Aug;22(4):431-5 - PubMed
  35. J Clin Neurosci. 2002 Jan;9(1):4-8 - PubMed
  36. Curr Top Med Chem. 2005;5(1):3-14 - PubMed
  37. Neuropsychiatr Dis Treat. 2007 Dec;3(6):811-21 - PubMed
  38. J Clin Neurol. 2006 Jun;2(2):126-33 - PubMed
  39. Am J Cardiol. 2005 Jul 15;96(2):243-51 - PubMed
  40. Neurology. 2005 Jun 28;64(12):2108-14 - PubMed
  41. Acta Neurol Scand. 2008 Sep;118(3):164-74 - PubMed
  42. Biol Psychiatry. 2000 Jun 15;47(12):1025-33 - PubMed
  43. J Neurol Neurosurg Psychiatry. 2000 Nov;69(5):636-41 - PubMed
  44. Lancet Neurol. 2011 Sep;10(9):819-28 - PubMed
  45. MedGenMed. 2006 Aug 23;8(3):46 - PubMed
  46. Epilepsy Behav. 2007 May;10(3):486-94 - PubMed
  47. Clin Interv Aging. 2010 Apr 26;5:89-99 - PubMed
  48. Am J Clin Nutr. 2012 Feb;95(2):297-308 - PubMed
  49. Neurol Int. 2009 Nov 16;1(1):e6 - PubMed
  50. Epilepsy Behav. 2007 Feb;10(1):32-7 - PubMed
  51. Epilepsy Behav. 2003 Oct;4(5):548-52 - PubMed
  52. JAMA. 2004 Feb 25;291(8):965-73 - PubMed
  53. Obesity (Silver Spring). 2012 Feb;20(2):330-42 - PubMed
  54. Epilepsy Behav. 2006 Aug;9(1):181-5 - PubMed
  55. Epilepsia. 2008 Jul;49(7):1180-5 - PubMed
  56. Adv Ther. 2002 May-Jun;19(3):126-8 - PubMed
  57. J Clin Neurosci. 2009 Dec;16(12):1588-91 - PubMed
  58. Expert Rev Neurother. 2006 Jan;6(1):19-31 - PubMed
  59. Ann Neurol. 2003 Jun;53(6):693-702 - PubMed
  60. Epilepsy Behav. 2007 Feb;10(1):16-25 - PubMed
  61. J Clin Psychopharmacol. 2006 Feb;26(1):61-6 - PubMed
  62. Psychol Rep. 2007 Feb;100(1):164-6 - PubMed
  63. CNS Drugs. 2008;22(1):27-47 - PubMed
  64. Bipolar Disord. 2006 Feb;8(1):15-27 - PubMed
  65. Eur J Neurol. 2008 Feb;15(2):190-5 - PubMed
  66. Neurology. 2006 Aug 8;67(3):400-6 - PubMed
  67. Epilepsia. 2012 Jan;53(1):e5-8 - PubMed
  68. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD003384 - PubMed
  69. Epilepsy Behav. 2009 Mar;14(3):459-64 - PubMed
  70. Neurology. 1999 Jan 15;52(2):321-7 - PubMed
  71. Neurology. 2011 Jan 11;76(2):131-7 - PubMed
  72. PLoS One. 2012;7(3):e33519 - PubMed
  73. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Oct;26(6):1035-9 - PubMed
  74. Epilepsia. 2002 Apr;43(4):399-402 - PubMed
  75. Obes Res. 2003 Jun;11(6):722-33 - PubMed
  76. Biol Psychiatry. 2007 May 1;61(9):1039-48 - PubMed
  77. Epilepsy Behav. 2005 May;6(3):373-81 - PubMed
  78. J Med Toxicol. 2012 Jun;8(2):145-52 - PubMed
  79. Epilepsy Behav. 2001 Dec;2(6):579-584 - PubMed
  80. Epilepsia. 2006;47 Suppl 2:24-7 - PubMed
  81. J Affect Disord. 1998 Sep;50(2-3):245-51 - PubMed
  82. Epilepsy Behav. 2006 Feb;8(1):181-91 - PubMed
  83. Epilepsy Behav. 2004 Dec;5(6):857-65 - PubMed
  84. Int Psychogeriatr. 2003 Sep;15(3):307-9 - PubMed
  85. Epilepsia. 2000 Sep;41(9):1167-78 - PubMed
  86. Bipolar Disord. 2002 Jun;4(3):207-13 - PubMed
  87. Epilepsy Curr. 2008 May-Jun;8(3):60-1 - PubMed
  88. Obes Rev. 2007 Mar;8 Suppl 1:13-7 - PubMed
  89. Epilepsy Behav. 2011 Apr;20(4):597-601 - PubMed
  90. Eur J Neurol. 2013 Jan;20(1):130-7 - PubMed
  91. Neuroscience. 2011 Jun 2;183:171-7 - PubMed
  92. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Oct;26(6):1203-6 - PubMed
  93. Pol J Pharmacol. 2002 Nov-Dec;54(6):557-66 - PubMed
  94. Neurology. 2005 Mar 8;64(5):792-8 - PubMed
  95. Acta Neurol Scand. 2005 Sep;112(3):144-50 - PubMed
  96. Neuropharmacology. 2000 Mar 3;39(5):881-8 - PubMed
  97. Ann N Y Acad Sci. 2003 May;993:25-34; discussion 48-53 - PubMed
  98. Epilepsy Behav. 2003 Oct;4 Suppl 2:S25-38 - PubMed
  99. Acta Neurol Scand. 2005 Oct;112(4):214-22 - PubMed
  100. Bipolar Disord. 1999 Sep;1(1):42-53 - PubMed
  101. Brain Res. 1999 Aug 7;837(1-2):263-9 - PubMed
  102. Epilepsia. 2000 Mar;41(3):338-41 - PubMed
  103. Nervenarzt. 2002 Jun;73(6):525-32 - PubMed
  104. Seizure. 2002 Jan;11(1):47-50 - PubMed
  105. Seizure. 2001 Dec;10(8):592-5 - PubMed
  106. JAMA. 2007 Oct 10;298(14):1641-51 - PubMed
  107. J Psychiatry Neurosci. 2011 Jul;36(4):250-5 - PubMed
  108. Neurology. 2006 Oct 10;67(7):1307-8 - PubMed
  109. Epilepsy Behav. 2009 Jan;14(1):202-9 - PubMed
  110. Epilepsy Res. 2007 Feb;73(2):173-80 - PubMed
  111. Epilepsia. 2004 Dec;45(12):1478-87 - PubMed
  112. Epilepsy Res. 2003 May;54(2-3):171-8 - PubMed
  113. Seizure. 2006 Jun;15(4):235-41 - PubMed
  114. Life Sci. 2001 Sep 28;69(19):2265-77 - PubMed
  115. Seizure. 2008 Jan;17(1):19-26 - PubMed
  116. Epilepsy Res. 2008 Feb;78(2-3):140-6 - PubMed
  117. J Neurotrauma. 2004 May;21(5):501-12 - PubMed
  118. Headache. 2011 Apr;51(4):554-8 - PubMed
  119. Epilepsy Behav. 2005 Dec;7(4):620-8 - PubMed

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