Display options
Cite
Sampaio RR, Ladeia AM, Meneses RB, et al. C-reactive protein is not correlated with endothelial dysfunction in overweight and obese women. J Clin Med Res. 2013;5(4):294-9doi: 10.4021/jocmr1418w.
Sampaio, R. R., Ladeia, A. M., Meneses, R. B., Lima, M. d. e. . L., & Guimaraes, A. C. (2013). C-reactive protein is not correlated with endothelial dysfunction in overweight and obese women. Journal of clinical medicine research, 5(4), 294-9. https://doi.org/10.4021/jocmr1418w
Sampaio, Raphael Ribeiro, et al. "C-reactive protein is not correlated with endothelial dysfunction in overweight and obese women." Journal of clinical medicine research vol. 5,4 (2013): 294-9. doi: https://doi.org/10.4021/jocmr1418w
Sampaio RR, Ladeia AM, Meneses RB, Lima Mde L, Guimaraes AC. C-reactive protein is not correlated with endothelial dysfunction in overweight and obese women. J Clin Med Res. 2013 Aug;5(4):294-9. doi: 10.4021/jocmr1418w. Epub 2013 Jun 21. PMID: 23864919; PMCID: PMC3712885.
Copy Download .nbib Format: NLM
Share it on

J Clin Med Res. 2013 Aug;5(4):294-9. doi: 10.4021/jocmr1418w. Epub 2013 Jun 21.

C-reactive protein is not correlated with endothelial dysfunction in overweight and obese women.

Journal of clinical medicine research

Raphael Ribeiro Sampaio, Ana Marice Ladeia, Romulo Bagano Meneses, Maria de Lourdes Lima, Armenio Costa Guimaraes

Affiliations

  1. Bahiana School of Medicine and Public Health, Bahia Foundation for the Development of Sciences, FBDC, Salvador, Bahia, Brazil.

PMID: 23864919 PMCID: PMC3712885 DOI: 10.4021/jocmr1418w

Abstract

BACKGROUND: Obesity is a complex and multifactorial disease, has an inflammatory pattern and is associated with higher cardiometabolic risk. There are recent reports associating an elevated C-Reactive Protein (CRP) with a microscopic endothelial dysfunction. The objective is to evaluate if there is an association between serum levels of CRP and endothelial function in women with overweight/obesity, as well as the correlation between CRP and anthropometric variables.

METHODS: This is a cross-sectional study that analyzed secondary data from patients treated in an institution of tertiary education, as part of the weight excess and cardiometabolic disease survey. The study included patients with overweight/obesity who had CRP and endothelial function tests already made and inserted into the survey database. The endothelial function was evaluated by: reactive hyperemia test (endothelium-dependent vasodilation). All tests were recorded and later analyzed by the same echocardiographer who performed the examination. Statistical analyses were realized in the Statistical Package for the Social Sciences (SPSS) version 14. It was considered statistically significant a P value < 0.05.

RESULTS: This study included 47, nonsmoker women. with a BMI of 32.37 ± 5.06 kg/m(2), median of CRP of 2.59 mg/L and flow-mediated dilation (FMD) of 8.75% ± 5.22%. There was no correlation between CRP and endothelial dysfunction in this population (rs = 0.08, P = 0.64). No correlation was observed between CRP and BMI. There were no differences of endothelial dysfunction variables and CRP in groups in use or not of medications (Hypolipidemic, antihypertensives and hypoglycemic agents).

CONCLUSION: There was no association between CRP and FMD and this can suggest that it is possible that the level of eNOS dysfunction associated with increased CRP is not enough to lead to macroscopic changes and harm vasodilation.

Keywords: C-reactive protein; Endothelial dysfunction; Flow-mediated vasodilation; Obesity

References

  1. J Am Coll Cardiol. 2002 Jan 16;39(2):257-65 - PubMed
  2. Chest. 2005 Jun;127(6):2254-63 - PubMed
  3. Am J Clin Nutr. 1992 Feb;55(2 Suppl):488S-494S - PubMed
  4. N Engl J Med. 2005 Jan 6;352(1):20-8 - PubMed
  5. Clin Sci (Lond). 2000 May;98(5):531-5 - PubMed
  6. N Engl J Med. 2001 Jun 28;344(26):1959-65 - PubMed
  7. Mol Med. 2008 Jul-Aug;14(7-8):485-92 - PubMed
  8. Hellenic J Cardiol. 2011 Jul-Aug;52(4):327-36 - PubMed
  9. JAMA. 1999 Dec 8;282(22):2131-5 - PubMed
  10. Circulation. 1999 Jun 29;99(25):3227-33 - PubMed
  11. Int J Obes Relat Metab Disord. 1998 Dec;22(12):1145-58 - PubMed
  12. Int J Mol Sci. 2011;12(5):3117-32 - PubMed
  13. Arq Bras Cardiol. 2010 Feb;94(2):255-61, 273-9, 260-6 - PubMed
  14. Atherosclerosis. 2009 Sep;206(1):61-8 - PubMed
  15. Circulation. 1999 Jul 20;100(3):230-5 - PubMed
  16. Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1425-32 - PubMed
  17. JAMA. 2001 Jul 4;286(1):64-70 - PubMed
  18. Eur Heart J. 2004 Oct;25(19):1754-60 - PubMed
  19. Obes Res. 1998 Sep;6 Suppl 2:51S-209S - PubMed
  20. Hypertension. 2011 Feb;57(2):231-7 - PubMed
  21. Diabetes Care. 2005 Aug;28(8):2048-50 - PubMed
  22. Circulation. 2002 Sep 17;106(12):1439-41 - PubMed
  23. Gastroenterol Hepatol (N Y). 2007 Nov;3(11):856-63 - PubMed
  24. Circulation. 2006 Feb 14;113(6):898-918 - PubMed
  25. Mediators Inflamm. 2010;2010: - PubMed

Publication Types