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Brulotte V, Leblond FA, Elkouri S, et al. Bicarbonates for the prevention of postoperative renal failure in endovascular aortic aneurysm repair: a randomized pilot trial. Anesthesiol Res Pract. 2013;2013:467326doi: 10.1155/2013/467326.
Brulotte, V., Leblond, F. A., Elkouri, S., Thérasse, E., Pichette, V., & Beaulieu, P. (2013). Bicarbonates for the prevention of postoperative renal failure in endovascular aortic aneurysm repair: a randomized pilot trial. Anesthesiology research and practice, 2013467326. https://doi.org/10.1155/2013/467326
Brulotte, Véronique, et al. "Bicarbonates for the prevention of postoperative renal failure in endovascular aortic aneurysm repair: a randomized pilot trial." Anesthesiology research and practice vol. 2013 (2013): 467326. doi: https://doi.org/10.1155/2013/467326
Brulotte V, Leblond FA, Elkouri S, Thérasse E, Pichette V, Beaulieu P. Bicarbonates for the prevention of postoperative renal failure in endovascular aortic aneurysm repair: a randomized pilot trial. Anesthesiol Res Pract. 2013;2013:467326. doi: 10.1155/2013/467326. Epub 2013 Jun 12. PMID: 23840204; PMCID: PMC3694372.
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Anesthesiol Res Pract. 2013;2013:467326. doi: 10.1155/2013/467326. Epub 2013 Jun 12.

Bicarbonates for the prevention of postoperative renal failure in endovascular aortic aneurysm repair: a randomized pilot trial.

Anesthesiology research and practice

Véronique Brulotte, François A Leblond, Stéphane Elkouri, Eric Thérasse, Vincent Pichette, Pierre Beaulieu

Affiliations

  1. Anesthesiology Department, University of Montreal Hospital Centre, 3840 St. Urbain Street, Montréal, QC, Canada H2W 1T8 ; Department of Anesthesiology, Maisonneuve-Rosemont Hospital, 5415 Boulevard de l'Assomption, Montréal, QC, Canada H1T 2M4.

PMID: 23840204 PMCID: PMC3694372 DOI: 10.1155/2013/467326

Abstract

Purpose. Contrast-induced nephropathy (CIN) can contribute to acute kidney injury (AKI) in patients undergoing endovascular aortic aneurysm surgery. We evaluated the incidence of AKI together with the evolution of early biomarkers of renal injury in patients receiving bicarbonates or NaCl 0.9%. Methods. This study involved endovascular aortic aneurysm surgery patients. Group A (n = 17) received bicarbonates 3 mL/kg/h for 1 h before the procedure and then 1 mL/kg/h until 6 h after surgery, whereas group B (n = 17) received NaCl 0.9% using the same protocol. Biomarkers of renal injury from urine (interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and kidney injury molecule 1 (KIM-1)) and blood (NGAL, cystatin C) were measured at baseline and 3, 24, and 48 h postoperatively. Results. AKI occurred in 1 patient (2.9%), in the bicarbonates group. IL-18, NAG, NGAL, and KIM-1 significantly rose in both groups after the surgery. There was a greater rise in NGAL and IL-18 after 3 h in the bicarbonates versus NaCl 0.9% group: 1115% versus 240% increase (P = 0.03) and 338% increase versus 1.4% decrease (P = 0.01). Conclusions. Despite significant elevation in biomarkers of renal injury, we demonstrated a low rate of AKI following endovascular aortic surgery.

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