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Sadowski M, Janion-Sadowska A, Gąsior M, et al. Higher mortality in women after ST-segment elevation myocardial infarction in very young patients. Arch Med Sci. 2013;9(3):427-33doi: 10.5114/aoms.2013.35324.
Sadowski, M., Janion-Sadowska, A., Gąsior, M., Gierlotka, M., Janion, M., & Poloński, L. (2013). Higher mortality in women after ST-segment elevation myocardial infarction in very young patients. Archives of medical science : AMS, 9(3), 427-33. https://doi.org/10.5114/aoms.2013.35324
Sadowski, Marcin, et al. "Higher mortality in women after ST-segment elevation myocardial infarction in very young patients." Archives of medical science : AMS vol. 9,3 (2013): 427-33. doi: https://doi.org/10.5114/aoms.2013.35324
Sadowski M, Janion-Sadowska A, Gąsior M, Gierlotka M, Janion M, Poloński L. Higher mortality in women after ST-segment elevation myocardial infarction in very young patients. Arch Med Sci. 2013 Jun 20;9(3):427-33. doi: 10.5114/aoms.2013.35324. Epub 2013 May 27. PMID: 23847662; PMCID: PMC3701974.
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Arch Med Sci. 2013 Jun 20;9(3):427-33. doi: 10.5114/aoms.2013.35324. Epub 2013 May 27.

Higher mortality in women after ST-segment elevation myocardial infarction in very young patients.

Archives of medical science : AMS

Marcin Sadowski, Agnieszka Janion-Sadowska, Mariusz Gąsior, Marek Gierlotka, Marianna Janion, Lech Poloński

Affiliations

  1. ?wi?tokrzyskie Cardiology Centre, Kielce, Poland.

PMID: 23847662 PMCID: PMC3701974 DOI: 10.5114/aoms.2013.35324

Abstract

INTRODUCTION: Data on mortality in young patients with ST-segment elevation myocardial infarction (STEMI) when compared to older people or regarding therapeutic strategies are contradictory. We investigate the prognosis of women under 40 after STEMI in a prospective nationwide acute coronary syndrome registry.

MATERIAL AND METHODS: We analyzed all 527 consecutive men and women (12.3% females) aged from 20 to 40 years (mean 35.7 ±4.5) presenting with STEMI, of all 26035 STEMI patients enrolled.

RESULTS: Differences between genders in the major cardiovascular risk factors, clinical presentation, extent of the disease and time to reperfusion were insignificant. The majority of patients (67%) underwent coronary angiography followed by primary percutaneous coronary intervention (PCI) in 79.9% of them. A 92% reperfusion success rate measured by post-procedural TIMI 3 flow was achieved. There were no significant differences between genders in the administration of modern pharmacotherapy both on admission and after discharge from hospital. In-hospital mortality was very low in both genders, but 12-month mortality was significantly higher in women (10.8% vs. 3.0%; p = 0.003). Killip class 3 or 4 on admission (95% CI 19.6-288.4), age per 5-year increase (95% CI 1.01-3.73) and primary PCI (95% CI 0.1-0.93) affected mortality. In patients who underwent reperfusion there was moderately higher mortality in women than in men (7.1% vs. 1.9%; p = 0.046).

CONCLUSIONS: Despite little difference in the basic clinical characteristics and the management including a wide use of primary PCI, long-term mortality in women under forty after STEMI is significantly higher than in men.

Keywords: ST-segment elevation myocardial infarction; gender-related difference; mortality; myocardial infarction; young

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