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Saddick SY. In vitro regulation of sheep ovarian surface epithelium (OSE) proliferation by local ovarian factors. Saudi J Biol Sci. 2012;19(3):285-90doi: 10.1016/j.sjbs.2012.03.003.
Saddick, S. Y. (2012). In vitro regulation of sheep ovarian surface epithelium (OSE) proliferation by local ovarian factors. Saudi journal of biological sciences, 19(3), 285-90. https://doi.org/10.1016/j.sjbs.2012.03.003
Saddick, Salina Yahya. "In vitro regulation of sheep ovarian surface epithelium (OSE) proliferation by local ovarian factors." Saudi journal of biological sciences vol. 19,3 (2012): 285-90. doi: https://doi.org/10.1016/j.sjbs.2012.03.003
Saddick SY. In vitro regulation of sheep ovarian surface epithelium (OSE) proliferation by local ovarian factors. Saudi J Biol Sci. 2012 Jul;19(3):285-90. doi: 10.1016/j.sjbs.2012.03.003. Epub 2012 Mar 30. PMID: 23961188; PMCID: PMC3730561.
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Saudi J Biol Sci. 2012 Jul;19(3):285-90. doi: 10.1016/j.sjbs.2012.03.003. Epub 2012 Mar 30.

In vitro regulation of sheep ovarian surface epithelium (OSE) proliferation by local ovarian factors.

Saudi journal of biological sciences

Salina Yahya Saddick

Affiliations

  1. Faculty of Science, Biology Department, King Abdulaziz University, Jeddah 21551, Saudi Arabia.

PMID: 23961188 PMCID: PMC3730561 DOI: 10.1016/j.sjbs.2012.03.003

Abstract

The ovarian surface epithelium (OSE) forms a lining around the entire ovary and actively participates in the ovulatory cycle. To investigate how specific growth factors and hormones affect OSE proliferation, the present study used sheep as a model to examine the effects of follicular and luteal products on the proliferation of sheep OSE cells in culture, and to analyse the influences of large antral follicles and corpora lutea (CL) on the expression of gonadotrophin receptors (FSHR and LHR) in the OSE. In the present study, follicular fluids from medium and large follicles, and extracts of corpora lutea stimulated the growth of OSE cells. The results of the present study showed that factors in the follicular fluid can induce OSE proliferative activity, and this stimulation effect could not be attributed to steroids in the follicular fluid since oestrogen and progesterone treatments failed to stimulate OSE cells. The expression of LH and FSH receptors over large follicles (5 mm or larger) was two and four times higher than those over stroma and CL, respectively. In conclusion, OSE proliferation in cycling sheep is associated with underlying developing follicles and CL, mediated by, at least in part, the up-regulation of gonadotrophin receptors, and facilitated by the action of mitogenic glycopeptides and growth factors, but not steroids.

Keywords: In vitro proliferation; Ovarian factors; Sheep ovarian surface epithelium

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