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Casazza K, Hanks LJ, Clines GA, et al. Diabetes-related impairment in bone strength is established early in the life course. World J Diabetes. 2013;4(4):145-50doi: 10.4239/wjd.v4.i4.145.
Casazza, K., Hanks, L. J., Clines, G. A., Tse, H. M., & Eberhardt, A. W. (2013). Diabetes-related impairment in bone strength is established early in the life course. World journal of diabetes, 4(4), 145-50. https://doi.org/10.4239/wjd.v4.i4.145
Casazza, Krista, et al. "Diabetes-related impairment in bone strength is established early in the life course." World journal of diabetes vol. 4,4 (2013): 145-50. doi: https://doi.org/10.4239/wjd.v4.i4.145
Casazza K, Hanks LJ, Clines GA, Tse HM, Eberhardt AW. Diabetes-related impairment in bone strength is established early in the life course. World J Diabetes. 2013 Aug 15;4(4):145-50. doi: 10.4239/wjd.v4.i4.145. PMID: 23961325; PMCID: PMC3746087.
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World J Diabetes. 2013 Aug 15;4(4):145-50. doi: 10.4239/wjd.v4.i4.145.

Diabetes-related impairment in bone strength is established early in the life course.

World journal of diabetes

Krista Casazza, Lynae J Hanks, Gregory A Clines, Hubert M Tse, Alan W Eberhardt

Affiliations

  1. Krista Casazza, Lynae J Hanks, Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294-3360, United States.

PMID: 23961325 PMCID: PMC3746087 DOI: 10.4239/wjd.v4.i4.145

Abstract

AIM: To evaluate properties of bone quantity/quality using young non-obese Type 1 (T1D)-diabetic (NOD) prone and syngenic non-diabetic (NOD.scid) mice.

METHODS: Quantitative bone assessment of tibia was conducted using dual-energy X-ray absorptiometry (DXA) for the evaluation of body mass, bone mineral content, body fat mass and lean mass. Qualitative assessment was accomplished by three-point breakage for assessment of force to failure and micro-computed tomography for evaluation of trabecular and cortical properties of bone. In addition, fasting blood was evaluated prior to sacrifice at week eleven and fifteen to evaluate and compare glucose homeostasis between the strains of mice.

RESULTS: Our findings support a perturbation in the relationship between bone quantity, quality, and subsequently, the association between structure and strength. There were no differences in DXA-assessed body composition (body fat, % fat mass and lean mass) and bone composition (bone mineral content and bone mineral density) between strains. However, relative to NOD.scid, NOD mice had lower trabecular bone volume, relative trabecular bone volume, trabecular number and trabecular total material density (P < 0.05). Conversely, NOD mice had greater cortical total mean volume (P < 0.05). General linear models analysis adjusted for body weight revealed a significant contribution of T1D to bone health as early as 5 wk.

CONCLUSION: It is well-established that diabetes is a significant risk factor for increased fractures, although the underlying mechanisms are not fully understood. Investigation of bone parameters encompassing strength and structure early in the life course will facilitate the elucidation of the pathogenesis of impaired bone integrity.

Keywords: Bone strength; Development and growth; Diabetes; Non-obese diabetic; Skeletal integrity

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