Display options
Cite
Aboul-Nasr MB, Zohri AN, Amer EM. Enzymatic and toxigenic ability of opportunistic fungi contaminating intensive care units and operation rooms at Assiut University Hospitals, Egypt. Springerplus. 2013;2:347doi: 10.1186/2193-1801-2-347.
Aboul-Nasr, M. B., Zohri, A. N., & Amer, E. M. (2013). Enzymatic and toxigenic ability of opportunistic fungi contaminating intensive care units and operation rooms at Assiut University Hospitals, Egypt. SpringerPlus, 2347. https://doi.org/10.1186/2193-1801-2-347
Aboul-Nasr, Mohamed Bassam, et al. "Enzymatic and toxigenic ability of opportunistic fungi contaminating intensive care units and operation rooms at Assiut University Hospitals, Egypt." SpringerPlus vol. 2 (2013): 347. doi: https://doi.org/10.1186/2193-1801-2-347
Aboul-Nasr MB, Zohri AN, Amer EM. Enzymatic and toxigenic ability of opportunistic fungi contaminating intensive care units and operation rooms at Assiut University Hospitals, Egypt. Springerplus. 2013 Jul 29;2:347. doi: 10.1186/2193-1801-2-347. eCollection 2013. PMID: 23961411; PMCID: PMC3733072.
Copy Download .nbib Format: NLM
Share it on

Springerplus. 2013 Jul 29;2:347. doi: 10.1186/2193-1801-2-347. eCollection 2013.

Enzymatic and toxigenic ability of opportunistic fungi contaminating intensive care units and operation rooms at Assiut University Hospitals, Egypt.

SpringerPlus

Mohamed Bassam Aboul-Nasr, Abdel-Naser Ahmed Zohri, Enas Mahmoud Amer

Affiliations

  1. Faculty of Science, Department of Botany, University of Sohag, Sohag, Egypt.

PMID: 23961411 PMCID: PMC3733072 DOI: 10.1186/2193-1801-2-347

Abstract

Total of 110 isolates belonging to 8 fungal species collected from intensive care units (ICUs) and operation rooms (ORs) at Assiut University hospitals were examined for their ability to produce some extracellular enzymes and mycotoxins which are considered as important factors involved in for fungal pathogenicity. The results revealed that 73, 92 and 78 out of the 110 tested isolates produced protease, lipase and urease respectively; meanwhile, 77 of the tested isolates exhibited some hemolytic activities. Chromatographic analysis (TLC) of the crude extract of the fungal isolates tested revealed that 79 isolates of them had the ability to produce at least one of these mycotoxic compounds (aflatoxins B1, B2, G1, gliotoxin, fumigillin, T-2, zearalenone, roridin A & E, verrucarin A & J, trichoveroids, satratoxin H & E). These results demonstrate that the opportunistic fungal species isolated from (ICUs) and (ORs) and tested exhibited some enzymatic and mycotoxic ability which are the most effective virulence factors contributing to fungal pathogenicity indicating that the management of infection control unit at Assiut University hospitals must be aware of not only bacterial but also fungal contamination.

Keywords: Airborne fungi; Enzymes; Mycotoxins and pathogenicity

References

  1. Zentralbl Bakteriol Orig A. 1974;229(2):264-7 - PubMed
  2. Infect Immun. 1984 Jan;43(1):320-5 - PubMed
  3. Toxicology. 2001 Oct 15;167(2):101-34 - PubMed
  4. Aliment Pharmacol Ther. 1996 Apr;10 Suppl 1:57-64 - PubMed
  5. Appl Environ Microbiol. 1985 Mar;49(3):678-81 - PubMed
  6. Infect Control Hosp Epidemiol. 2006 Jan;27(1):44-7 - PubMed
  7. J Hosp Infect. 2002 Feb;50(2):155-60 - PubMed
  8. J Dairy Sci. 1993 Mar;76(3):892-7 - PubMed
  9. Infect Immun. 1995 May;63(5):1993-8 - PubMed
  10. Infect Immun. 1991 Jul;59(7):2470-5 - PubMed
  11. Nat Rev Microbiol. 2005 Dec;3(12):937-47 - PubMed
  12. J Appl Toxicol. 2006 May-Jun;26(3):229-38 - PubMed
  13. Science. 1981 Nov 20;214(4523):877-80 - PubMed
  14. Science. 1973 Aug 24;181(4101):758-60 - PubMed
  15. Int J Hyg Environ Health. 2005;208(4):279-85 - PubMed
  16. Int J Med Microbiol. 2002 Oct;292(5-6):405-19 - PubMed
  17. J Exp Med. 1992 Feb 1;175(2):517-25 - PubMed
  18. J Biomol Struct Dyn. 2000 Apr;17(5):787-97 - PubMed
  19. Chemotherapy. 2005 Mar;51(1):21-6 - PubMed
  20. Clin Microbiol Rev. 2005 Jan;18(1):44-69 - PubMed
  21. Appl Environ Microbiol. 1999 Jul;65(7):3175-81 - PubMed
  22. Am J Vet Res. 1988 Oct;49(10):1766-73 - PubMed
  23. Clin Microbiol Infect. 2006 Nov;12(11):1060-76 - PubMed
  24. Infect Immun. 1988 Mar;56(3):626-31 - PubMed
  25. Appl Environ Microbiol. 1983 May;45(5):1419-22 - PubMed
  26. Med Mycol. 2009;47 Suppl 1:S261-70 - PubMed
  27. Infect Immun. 2000 Feb;68(2):443-8 - PubMed
  28. Infect Immun. 2001 Feb;69(2):912-6 - PubMed
  29. Mycoses. 1993 Nov-Dec;36(11-12):351-6 - PubMed
  30. Microbiology (Reading). 2013 Aug;159(Pt 8):1720-1724 - PubMed
  31. J Hosp Infect. 2006 Jul;63(3):246-54 - PubMed
  32. Environ Health Perspect. 2006 Jul;114(7):1099-107 - PubMed
  33. J Hosp Infect. 2001 Jul;48(3):198-206 - PubMed
  34. J Org Chem. 1977 Jan 21;42(2):240-3 - PubMed
  35. Med Mycol. 2004 Feb;42(1):81-6 - PubMed
  36. FEMS Microbiol Lett. 1993 Jan 1;106(1):39-46 - PubMed
  37. Nat Toxins. 1998;6(5):211-8 - PubMed
  38. Int J Med Microbiol. 2008 Apr;298(3-4):319-27 - PubMed
  39. Fungal Genet Biol. 2003 Jul;39(2):103-17 - PubMed

Publication Types