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Quintanar JL, Guzmán-Soto I. Hypothalamic neurohormones and immune responses. Front Integr Neurosci. 2013;7:56doi: 10.3389/fnint.2013.00056.
Quintanar, J. L., & Guzmán-Soto, I. (2013). Hypothalamic neurohormones and immune responses. Frontiers in integrative neuroscience, 756. https://doi.org/10.3389/fnint.2013.00056
Quintanar, J Luis, and Guzmán-Soto, Irene. "Hypothalamic neurohormones and immune responses." Frontiers in integrative neuroscience vol. 7 (2013): 56. doi: https://doi.org/10.3389/fnint.2013.00056
Quintanar JL, Guzmán-Soto I. Hypothalamic neurohormones and immune responses. Front Integr Neurosci. 2013 Aug 13;7:56. doi: 10.3389/fnint.2013.00056. eCollection 2013. PMID: 23964208; PMCID: PMC3741963.
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Front Integr Neurosci. 2013 Aug 13;7:56. doi: 10.3389/fnint.2013.00056. eCollection 2013.

Hypothalamic neurohormones and immune responses.

Frontiers in integrative neuroscience

J Luis Quintanar, Irene Guzmán-Soto

Affiliations

  1. Laboratory of Neurophysiology, Department of Physiology and Pharmacology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes Aguascalientes, México.

PMID: 23964208 PMCID: PMC3741963 DOI: 10.3389/fnint.2013.00056

Abstract

The aim of this review is to provide a comprehensive examination of the current literature describing the neural-immune interactions, with emphasis on the most recent findings of the effects of neurohormones on immune system. Particularly, the role of hypothalamic hormones such as Thyrotropin-releasing hormone (TRH), Corticotropin-releasing hormone (CRH) and Gonadotropin-releasing hormone (GnRH). In the past few years, interest has been raised in extrapituitary actions of these neurohormones due to their receptors have been found in many non-pituitary tissues. Also, the receptors are present in immune cells, suggesting an autocrine or paracrine role within the immune system. In general, these neurohormones have been reported to exert immunomodulatory effects on cell proliferation, immune mediators release and cell function. The implications of these findings in understanding the network of hypothalamic neuropeptides and immune system are discussed.

Keywords: CRF; CRH; GnRH; LHRH; TRH; extrapituitary; immune system; receptors

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