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Lee EJ, Kim JY, Kim DR, et al. Glycemic index of dietary formula may not be predictive of postprandial endothelial inflammation: a double-blinded, randomized, crossover study in non-diabetic subjects. Nutr Res Pract. 2013;7(4):302-8doi: 10.4162/nrp.2013.7.4.302.
Lee, E. J., Kim, J. Y., Kim, D. R., Kim, K. S., Kim, M. K., & Kwon, O. (2013). Glycemic index of dietary formula may not be predictive of postprandial endothelial inflammation: a double-blinded, randomized, crossover study in non-diabetic subjects. Nutrition research and practice, 7(4), 302-8. https://doi.org/10.4162/nrp.2013.7.4.302
Lee, Eun Ju, et al. "Glycemic index of dietary formula may not be predictive of postprandial endothelial inflammation: a double-blinded, randomized, crossover study in non-diabetic subjects." Nutrition research and practice vol. 7,4 (2013): 302-8. doi: https://doi.org/10.4162/nrp.2013.7.4.302
Lee EJ, Kim JY, Kim DR, Kim KS, Kim MK, Kwon O. Glycemic index of dietary formula may not be predictive of postprandial endothelial inflammation: a double-blinded, randomized, crossover study in non-diabetic subjects. Nutr Res Pract. 2013 Aug;7(4):302-8. doi: 10.4162/nrp.2013.7.4.302. Epub 2013 Aug 07. PMID: 23964318; PMCID: PMC3746165.
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Nutr Res Pract. 2013 Aug;7(4):302-8. doi: 10.4162/nrp.2013.7.4.302. Epub 2013 Aug 07.

Glycemic index of dietary formula may not be predictive of postprandial endothelial inflammation: a double-blinded, randomized, crossover study in non-diabetic subjects.

Nutrition research and practice

Eun Ju Lee, Ji Yeon Kim, Do Ram Kim, Kyoung Soo Kim, Mi Kyung Kim, Oran Kwon

Affiliations

  1. Department of Nutritional Science and Food Management, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Korea.

PMID: 23964318 PMCID: PMC3746165 DOI: 10.4162/nrp.2013.7.4.302

Abstract

The emerging role of endothelial inflammation in diabetes has stimulated research interest in the effects of nutrition on related indices. In the current study we investigated whether the nutrient composition of dietary formula as reflected in glycemic index (GI) may be predictive of postprandial endothelial inflammation in non-diabetic subjects. A double-blinded, randomized, crossover study was conducted in non-diabetic subjects (n = 8/group). Each subject consumed three types of diabetes-specific dietary formulas (high-fiber formula [FF], high-monounsaturated fatty acid (MUFA) formula [MF] and control formula [CF]) standardized to 50 g of available carbohydrates with a 1-week interval between each. The mean glycemic index (GI) was calculated and 3-hour postprandial responses of insulin, soluble intercellular adhesion molecule-1 (sICAM-1), nitrotyrosine (NT) and free fatty acids (FFA) were measured. The MF showed the lowest mean GI and significantly low area under the curve (AUC) for insulin (P = 0.038), but significantly high AUCs for sICAM-1 (P < 0.001) and FFA (P < 0.001) as compared to the CF and FF. The FF showed intermediate mean GI, but significantly low AUC for NT (P < 0.001) as compared to the CF and MF. The mean GI was not positively correlated to any of the inflammatory markers evaluated, and in fact negatively correlated to changes in FFA (r = -0.473, P = 0.006). While the MF with the lowest GI showed the highest values in most of the inflammatory markers measured, the FF with intermediate GI had a modest beneficial effect on endothelial inflammation. These results suggest that nutrient composition of dietary formula as reflected in the GI may differently influence acute postprandial inflammation in non-diabetic subjects.

Keywords: Diabetes-specific dietary formula; endothelial inflammation; glycemic index

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