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Falcao RA, do Nascimento PL, de Souza SA, et al. Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit. Evid Based Complement Alternat Med. 2013;2013:460613doi: 10.1155/2013/460613.
Falcao, R. A., do Nascimento, P. L., de Souza, S. A., da Silva, T. M., de Queiroz, A. C., da Matta, C. B., Moreira, M. S., Camara, C. A., & Silva, T. M. (2013). Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit. Evidence-based complementary and alternative medicine : eCAM, 2013460613. https://doi.org/10.1155/2013/460613
Falcao, Rosangela A, et al. "Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 460613. doi: https://doi.org/10.1155/2013/460613
Falcao RA, do Nascimento PL, de Souza SA, da Silva TM, de Queiroz AC, da Matta CB, Moreira MS, Camara CA, Silva TM. Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit. Evid Based Complement Alternat Med. 2013;2013:460613. doi: 10.1155/2013/460613. Epub 2013 Jul 28. PMID: 23983783; PMCID: PMC3745876.
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Evid Based Complement Alternat Med. 2013;2013:460613. doi: 10.1155/2013/460613. Epub 2013 Jul 28.

Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit.

Evidence-based complementary and alternative medicine : eCAM

Rosangela A Falcao, Patricia L A do Nascimento, Silvana A de Souza, Telma M G da Silva, Aline C de Queiroz, Carolina B B da Matta, Magna S A Moreira, Celso A Camara, Tania M S Silva

Affiliations

  1. Laboratório de Bioprospecção Fitoquímica, Departamento de Ciências Moleculares, Universidade Federal Rural de Pernambuco, 52171-900 Recife, Pernambuco, Brazil.

PMID: 23983783 PMCID: PMC3745876 DOI: 10.1155/2013/460613

Abstract

Hyptis pectinata, popularly known in Brazil as "sambacaitá" or "canudinho," is an aromatic shrub largely grown in the northeast of Brazil. The leaves and bark are used in an infusion for the treatment of throat and skin inflammations, bacterial infections, pain, and cancer. Analogues of rosmarinic acid and flavonoids were obtained from the leaves of Hyptis pectinata and consisted of two new compounds, sambacaitaric acid (1) and 3-O-methyl-sambacaitaric acid (2), and nine known compounds, rosmarinic acid (3), 3-O-methyl-rosmarinic acid (4), ethyl caffeate (5), nepetoidin A (6), nepetoidin B (7), cirsiliol (8), circimaritin (9), 7-O-methylluteolin (10), and genkwanin (11). The structures of these compounds were determined by spectroscopic methods. Compounds 1-5, and 7 were evaluated in vitro against the promastigote form of L. braziliensis, and the ethanol extract. The hexane, ethyl acetate, and methanol-water fractions were also evaluated. The EtOH extract, the hexane extract, EtOAc, MeOH:H2O fractions; and compounds 1, 2 and 4 exhibited antileishmanial activity, and compound 1 was as potent as pentamidine. In contrast, compounds 3, 5, and 7 did not present activity against the promastigote form of L. braziliensis below 100 µM. To our knowledge, compounds 1 and 2 are being described for the first time.

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