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Adebayo JO, Balogun EA, Malomo SO, et al. Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies. Evid Based Complement Alternat Med. 2013;2013:742476doi: 10.1155/2013/742476.
Adebayo, J. O., Balogun, E. A., Malomo, S. O., Soladoye, A. O., Olatunji, L. A., Kolawole, O. M., Oguntoye, O. S., Babatunde, A. S., Akinola, O. B., Aguiar, A. C., Andrade, I. M., Souza, N. B., & Krettli, A. U. (2013). Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies. Evidence-based complementary and alternative medicine : eCAM, 2013742476. https://doi.org/10.1155/2013/742476
Adebayo, J O, et al. "Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 742476. doi: https://doi.org/10.1155/2013/742476
Adebayo JO, Balogun EA, Malomo SO, Soladoye AO, Olatunji LA, Kolawole OM, Oguntoye OS, Babatunde AS, Akinola OB, Aguiar AC, Andrade IM, Souza NB, Krettli AU. Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies. Evid Based Complement Alternat Med. 2013;2013:742476. doi: 10.1155/2013/742476. Epub 2013 Jul 30. PMID: 23983800; PMCID: PMC3745858.
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Evid Based Complement Alternat Med. 2013;2013:742476. doi: 10.1155/2013/742476. Epub 2013 Jul 30.

Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies.

Evidence-based complementary and alternative medicine : eCAM

J O Adebayo, E A Balogun, S O Malomo, A O Soladoye, L A Olatunji, O M Kolawole, O S Oguntoye, A S Babatunde, O B Akinola, A C C Aguiar, I M Andrade, N B Souza, A U Krettli

Affiliations

  1. Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.

PMID: 23983800 PMCID: PMC3745858 DOI: 10.1155/2013/742476

Abstract

In this study, the antimalarial and toxicity potentials of husk fibre extracts of five Nigerian varieties of Cocos nucifera were evaluated in vitro. The only active extract fraction, West African Tall (WAT) ethyl acetate extract fraction, was then evaluated for its phytochemical constituents, antimalarial and toxicity potentials at varying doses (31.25-500 mg/kg body weight) using various organ function indices. The results revealed that WAT ethyl acetate extract fraction (WATEAEF) contained alkaloids, tannins, and flavonoids and was active against Plasmodium falciparum W2 strain maintained in continuous culture, with a selectivity index of 30.3. The same extract fraction was active in vivo against Plasmodium berghei NK65, causing more than 50% reduction in parasitaemia on days 4 and 6 after inoculation at various doses administered. WATEAEF did not significantly alter (P > 0.05) function indices of the liver and cardiovascular system at all doses administered but significantly increased (P < 0.05) plasma creatinine concentration at 250 and 500 mg/Kg body weight compared to controls. The results of this study suggest that WATEAEF possesses antimalarial activity and may not adversely affect normal liver function nor predispose subjects to cardiovascular diseases but may impair normal kidney function at higher doses. Further studies are underway to isolate the active principles.

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