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Bhasin R, Ghobrial I. Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes. J Community Hosp Intern Med Perspect. 2013;3(1)doi: 10.3402/jchimp.v3i1.20494.
Bhasin, R., & Ghobrial, I. (2013). Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes. Journal of community hospital internal medicine perspectives, 3(1), . https://doi.org/10.3402/jchimp.v3i1.20494
Bhasin, Robin, and Ghobrial, Ibrahim. "Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes." Journal of community hospital internal medicine perspectives vol. 3,1 (2013). doi: https://doi.org/10.3402/jchimp.v3i1.20494
Bhasin R, Ghobrial I. Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes. J Community Hosp Intern Med Perspect. 2013 Apr 17;3(1). doi: 10.3402/jchimp.v3i1.20494. Print 2013. PMID: 23882392; PMCID: PMC3716030.
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J Community Hosp Intern Med Perspect. 2013 Apr 17;3(1). doi: 10.3402/jchimp.v3i1.20494. Print 2013.

Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes.

Journal of community hospital internal medicine perspectives

Robin Bhasin, Ibrahim Ghobrial

Affiliations

  1. Department of Medicine, University of Pittsburgh Medical Center-Mckeesport, Mckeesport PA, USA.

PMID: 23882392 PMCID: PMC3716030 DOI: 10.3402/jchimp.v3i1.20494

Abstract

A 51-year-old female with a history of type 1 diabetes mellitus (DM) presented with sudden onset of pain and swelling of the left thigh. Her initial evaluation revealed mildly elevated erythrocyte sedimentation rate and creatine phosphokinase. Venous and arterial Doppler studies were negative for DVT and arterial thrombus. Further imaging with CT scan and then MRI revealed an irregular, enhancing space-occupying lesion of the left upper and mid-thigh. Subsequent muscle biopsy showed myonecrosis and proliferative myositis. Both findings are consistent with diabetic myonecrosis, which is a microvascular complication of long-standing poorly controlled DM. The patient was treated with analgesics, supportive care, and optimization of glycemic control. While short-term prognosis is good with adequate healing in a few weeks to several months, long-term prognosis is poor due to underlying extensive vascular disease. Although radiological findings are very suggestive of the diagnosis, most clinicians still need tissue biopsy to rule out other serious conditions such as infections and malignancy.

Keywords: diabetes mellitus; diabetic myonecrosis; microvascular complications; proliferative myositis

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