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Kee HL, Verhey KJ. Molecular connections between nuclear and ciliary import processes. Cilia. 2013;2(1):11doi: 10.1186/2046-2530-2-11.
Kee, H. L., & Verhey, K. J. (2013). Molecular connections between nuclear and ciliary import processes. Cilia, 2(1), 11. https://doi.org/10.1186/2046-2530-2-11
Kee, H Lynn, and Verhey, Kristen J. "Molecular connections between nuclear and ciliary import processes." Cilia vol. 2,1 (2013): 11. doi: https://doi.org/10.1186/2046-2530-2-11
Kee HL, Verhey KJ. Molecular connections between nuclear and ciliary import processes. Cilia. 2013 Aug 28;2(1):11. doi: 10.1186/2046-2530-2-11. PMID: 23985042; PMCID: PMC3765448.
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Cilia. 2013 Aug 28;2(1):11. doi: 10.1186/2046-2530-2-11.

Molecular connections between nuclear and ciliary import processes.

Cilia

H Lynn Kee, Kristen J Verhey

Affiliations

  1. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. [email protected].

PMID: 23985042 PMCID: PMC3765448 DOI: 10.1186/2046-2530-2-11

Abstract

As an organelle, the cilium contains a unique complement of protein and lipid. Recent work has begun to shed light on the mechanisms that regulate entry of ciliary proteins into the compartment. Here, we focus on the mechanisms that regulate ciliary entry of cytosolic molecules. Studies have revealed a size exclusion mechanism for ciliary entry that is similar to the barrier to nuclear entry. Active import into the ciliary compartment involves nuclear trafficking components including importins, a Ran-guanosine triphosphate gradient, and nucleoporins. Together, this work indicates that nuclei and cilia share molecular, structural and mechanistic components that regulate import into the compartments.

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