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Rennert RC, Sorkin M, Garg RK, et al. Cellular response to a novel fetal acellular collagen matrix: implications for tissue regeneration. Int J Biomater. 2013;2013:527957doi: 10.1155/2013/527957.
Rennert, R. C., Sorkin, M., Garg, R. K., Januszyk, M., & Gurtner, G. C. (2013). Cellular response to a novel fetal acellular collagen matrix: implications for tissue regeneration. International journal of biomaterials, 2013527957. https://doi.org/10.1155/2013/527957
Rennert, Robert C, et al. "Cellular response to a novel fetal acellular collagen matrix: implications for tissue regeneration." International journal of biomaterials vol. 2013 (2013): 527957. doi: https://doi.org/10.1155/2013/527957
Rennert RC, Sorkin M, Garg RK, Januszyk M, Gurtner GC. Cellular response to a novel fetal acellular collagen matrix: implications for tissue regeneration. Int J Biomater. 2013;2013:527957. doi: 10.1155/2013/527957. Epub 2013 Jul 22. PMID: 23970899; PMCID: PMC3736474.
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Int J Biomater. 2013;2013:527957. doi: 10.1155/2013/527957. Epub 2013 Jul 22.

Cellular response to a novel fetal acellular collagen matrix: implications for tissue regeneration.

International journal of biomaterials

Robert C Rennert, Michael Sorkin, Ravi K Garg, Michael Januszyk, Geoffrey C Gurtner

Affiliations

  1. Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305-5148, USA.

PMID: 23970899 PMCID: PMC3736474 DOI: 10.1155/2013/527957

Abstract

Introduction. PriMatrix (TEI Biosciences Inc., Boston, MA, USA) is a novel acellular collagen matrix derived from fetal bovine dermis that is designed for use in partial- and full-thickness wounds. This study analyzes the cellular response to PriMatrix in vivo, as well as the ability of this matrix to facilitate normal tissue regeneration. Methods. Five by five mm squares of rehydrated PriMatrix were implanted in a subcutaneous fashion on the dorsum of wild-type mice. Implant site tissue was harvested for histology, immunohistochemistry (IHC), and flow cytometric analyses at multiple time points until day 28. Results. PriMatrix implants were found to go through a biological progression initiated by a transient infiltrate of inflammatory cells, followed by mesenchymal cell recruitment and vascular development. IHC analysis revealed that the majority of the implanted fetal dermal collagen fibers persisted through day 28 but underwent remodeling and cellular repopulation to form tissue with a density and morphology consistent with healthy dermis. Conclusions. PriMatrix implants undergo progressive in vivo remodeling, facilitating the regeneration of histologically normal tissue through a mild inflammatory and progenitor cell response. Regeneration of normal tissue is especially important in a wound environment, and these findings warrant further investigation of PriMatrix in this setting.

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