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Koslov DS, Andersson KE. Physiological and pharmacological aspects of the vas deferens-an update. Front Pharmacol. 2013;4:101doi: 10.3389/fphar.2013.00101.
Koslov, D. S., & Andersson, K. E. (2013). Physiological and pharmacological aspects of the vas deferens-an update. Frontiers in pharmacology, 4101. https://doi.org/10.3389/fphar.2013.00101
Koslov, David S, and Andersson, Karl-Erik. "Physiological and pharmacological aspects of the vas deferens-an update." Frontiers in pharmacology vol. 4 (2013): 101. doi: https://doi.org/10.3389/fphar.2013.00101
Koslov DS, Andersson KE. Physiological and pharmacological aspects of the vas deferens-an update. Front Pharmacol. 2013 Aug 22;4:101. doi: 10.3389/fphar.2013.00101. eCollection 2013. PMID: 23986701; PMCID: PMC3749770.
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Front Pharmacol. 2013 Aug 22;4:101. doi: 10.3389/fphar.2013.00101. eCollection 2013.

Physiological and pharmacological aspects of the vas deferens-an update.

Frontiers in pharmacology

David S Koslov, Karl-Erik Andersson

Affiliations

  1. Wake Forest Baptist Medical Center, Medical Center Boulevard Winston-Salem, NC, USA.

PMID: 23986701 PMCID: PMC3749770 DOI: 10.3389/fphar.2013.00101

Abstract

The vas deferens, a muscular conduit conveying spermatozoa from the epididymis to the urethra, has been used as a model tissue for smooth muscle pharmacological and physiological advancements. Many drugs, notably α-adrenergic antagonists, have effects on contractility and thus normal ejaculation, incurring significant side effects for patients that may interfere with compliance. A more thorough understanding of the innervation and neurotransmitter pharmacology of the vas has indicated that this is a highly complex structure and a model for co-transmission at the synapse. Recent models have shown clinical scenarios that alter the vas contraction. This review covers structure, receptors, neurotransmitters, smooth muscle physiology, and clinical implications of the vas deferens.

Keywords: adrenergic receptors; contraction; fertility; purinergic receptors; smooth muscle; vas deferens

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