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Antonini D, Sibilio A, Dentice M, et al. An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression. Front Endocrinol (Lausanne). 2013;4:104doi: 10.3389/fendo.2013.00104.
Antonini, D., Sibilio, A., Dentice, M., & Missero, C. (2013). An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression. Frontiers in endocrinology, 4104. https://doi.org/10.3389/fendo.2013.00104
Antonini, Dario, et al. "An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression." Frontiers in endocrinology vol. 4 (2013): 104. doi: https://doi.org/10.3389/fendo.2013.00104
Antonini D, Sibilio A, Dentice M, Missero C. An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression. Front Endocrinol (Lausanne). 2013 Aug 22;4:104. doi: 10.3389/fendo.2013.00104. eCollection 2013. PMID: 23986743; PMCID: PMC3749490.
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Front Endocrinol (Lausanne). 2013 Aug 22;4:104. doi: 10.3389/fendo.2013.00104. eCollection 2013.

An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression.

Frontiers in endocrinology

Dario Antonini, Annarita Sibilio, Monica Dentice, Caterina Missero

Affiliations

  1. CEINGE Biotecnologie Avanzate , Napoli , Italy.

PMID: 23986743 PMCID: PMC3749490 DOI: 10.3389/fendo.2013.00104

Abstract

Skin is the largest organ of the human body and plays a key role in protecting the individual from external insults. The barrier function of the skin is performed primarily by the epidermis, a self-renewing stratified squamous epithelium composed of cells that undergo a well-characterized and finely tuned process of terminal differentiation. By binding to their receptors thyroid hormones (TH) regulate epidermal cell proliferation, differentiation, and homeostasis. Thyroid dysfunction has multiple classical manifestations at skin level. Several TH-responsive genes, as well as genes critical for TH metabolism and action, are expressed at epidermal level. The role of TH in skin is still controversial, although it is generally recognized that TH signaling is central for skin physiology and homeostasis. Here we review the data on the epidermis and its function in relation to TH metabolism and regulation of gene expression. An understanding of the cellular and molecular basis of TH action in epidermal cells may lead to the identification of putative therapeutical targets for treatment of skin disorders.

Keywords: deiodinase; epidermal development; regulation of gene expression; skin; thyroid hormones

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