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Noonan T, Lukas S, Peet GW, et al. The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function. Am J Clin Exp Immunol. 2013;2(2):172-85
Noonan, T., Lukas, S., Peet, G. W., Pelletier, J., Panzenbeck, M., Hanidu, A., Mazurek, S., Wasti, R., Rybina, I., Roma, T., Kronkaitis, A., Shoultz, A., Souza, D., Jiang, H., Nabozny, G., & Modis, L. K. (2013). The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function. American journal of clinical and experimental immunology, 2(2), 172-85.
Noonan, Thomas, et al. "The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function." American journal of clinical and experimental immunology vol. 2,2 (2013): 172-85.
Noonan T, Lukas S, Peet GW, Pelletier J, Panzenbeck M, Hanidu A, Mazurek S, Wasti R, Rybina I, Roma T, Kronkaitis A, Shoultz A, Souza D, Jiang H, Nabozny G, Modis LK. The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function. Am J Clin Exp Immunol. 2013 Jun 15;2(2):172-85. Print 2013. PMID: 23885334; PMCID: PMC3714173.
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Am J Clin Exp Immunol. 2013 Jun 15;2(2):172-85. Print 2013.

The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.

American journal of clinical and experimental immunology

Thomas Noonan, Susan Lukas, Gregory W Peet, Josephine Pelletier, Mark Panzenbeck, Adedayo Hanidu, Suzanne Mazurek, Ruby Wasti, Irina Rybina, Teresa Roma, Anthony Kronkaitis, Alycia Shoultz, Donald Souza, Huiping Jiang, Gerald Nabozny, Louise Kelly Modis

Affiliations

  1. Boehringer Ingelheim Pharmaceuticals 900 Ridgebury Road, Ridgefield, CT 06877.

PMID: 23885334 PMCID: PMC3714173

Abstract

Vascular adhesion protein-1 (VAP-1) has been implicated in the pathogenesis of inflammatory diseases and is suggested to play a role in immune cell trafficking. It is not clear whether this effect is mediated by the oxidase activity or by other features of the protein such as direct adhesion. In order to study the role of VAP-1 oxidase activity in vivo, we have generated mice carrying an oxidase activity-null VAP-1 protein. We demonstrate that the VAP-1 oxidase null mutant mice have a phenotype similar to the VAP-1 null mice in animal models of sterile peritonitis and antibody induced arthritis suggesting that the oxidase activity is responsible for the inflammatory function of VAP-1.

Keywords: Vascular adhesion protein-1 (VAP-1); immune cell trafficking; inflammatory function; oxidase activity; semicarbazide-sensitive amine oxidase

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