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Neurobehav HIV Med. 2012 Feb 16;2012(4):15-34. doi: 10.2147/NBHIV.S17408.

Substance Abuse, Hepatitis C, and Aging in HIV: Common Cofactors that Contribute to Neurobehavioral Disturbances.

Neurobehavioral HIV medicine

Randi Melissa Schuster, Raul Gonzalez

Affiliations

  1. Department of Psychology, University of Illinois at Chicago, Chicago, Illinois, USA.

PMID: 24014165 PMCID: PMC3763847 DOI: 10.2147/NBHIV.S17408

Abstract

Although the prevalence of neurocognitive disturbances among individuals with HIV has decreased in recent years, rates of impairment still remain high. This review presents findings from comorbid conditions that may contribute to further neurocognitive impairments in this already vulnerable population. We will focus on three co-factors that have received substantial attention in the neuroAIDS literature: drug use, hepatitis C co-infection (HCV), and aging. All three conditions commonly co-occur with HIV and likely interact with HIV in complex ways. Collectively, the extant literature suggests that drug use, HCV, and aging serve to worsen the neurocognitive profile of HIV through several overlapping mechanisms. A better understanding of how specific comorbidities interact with HIV may reveal specific phenotypes of HIV-associated neurocognitive disorder that may aid in the development of more targeted behavioral and pharmacological treatment efforts.

Keywords: Aging; HIV; HIV Co-Factors; Hepatitis C; Neurocognition; Substance Use

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