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Ye R, Scherer PE. Adiponectin, driver or passenger on the road to insulin sensitivity?. Mol Metab. 2013;2(3):133-41doi: 10.1016/j.molmet.2013.04.001.
Ye, R., & Scherer, P. E. (2013). Adiponectin, driver or passenger on the road to insulin sensitivity?. Molecular metabolism, 2(3), 133-41. https://doi.org/10.1016/j.molmet.2013.04.001
Ye, Risheng, and Scherer, Philipp E. "Adiponectin, driver or passenger on the road to insulin sensitivity?." Molecular metabolism vol. 2,3 (2013): 133-41. doi: https://doi.org/10.1016/j.molmet.2013.04.001
Ye R, Scherer PE. Adiponectin, driver or passenger on the road to insulin sensitivity?. Mol Metab. 2013 Apr 19;2(3):133-41. doi: 10.1016/j.molmet.2013.04.001. PMID: 24049728; PMCID: PMC3773837.
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Mol Metab. 2013 Apr 19;2(3):133-41. doi: 10.1016/j.molmet.2013.04.001.

Adiponectin, driver or passenger on the road to insulin sensitivity?.

Molecular metabolism

Risheng Ye, Philipp E Scherer

Affiliations

  1. Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

PMID: 24049728 PMCID: PMC3773837 DOI: 10.1016/j.molmet.2013.04.001

Abstract

Almost 20 years have passed since the first laboratory evidence emerged that an abundant message encoding a protein with homology to the C1q superfamily is highly specifically expressed in adipocytes. At this stage, we refer to this protein as adiponectin. Despite more than 10,000 reports in the literature since its initial description, we seem to have written only the first chapter in the textbook on adiponectin physiology. With every new aspect we learn about adiponectin, a host of new questions arise with respect to the underlying molecular mechanisms. Here, we aim to summarize recent findings in the field and bring the rodent studies that suggest a causal relationship between adiponectin levels in plasma and systemic insulin sensitivity in perspective with the currently available data on the clinical side.

Keywords: AMPK; AdipoR; Ceramide; Human; Insulin sensitivity; Mouse; Oligomeric complexes

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