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Rafay AM. In-vitro activity of synercid and related drugs against Streptococcus oralis isolated from septicaemia and endocarditis cases. J Sci Res Med Sci. 2000;2(1):25-31
Rafay, A. M. (2000). In-vitro activity of synercid and related drugs against Streptococcus oralis isolated from septicaemia and endocarditis cases. Journal for scientific research. Medical sciences, 2(1), 25-31.
Rafay, A M. "In-vitro activity of synercid and related drugs against Streptococcus oralis isolated from septicaemia and endocarditis cases." Journal for scientific research. Medical sciences vol. 2,1 (2000): 25-31.
Rafay AM. In-vitro activity of synercid and related drugs against Streptococcus oralis isolated from septicaemia and endocarditis cases. J Sci Res Med Sci. 2000 Jan;2(1):25-31. PMID: 24019702; PMCID: PMC3174699.
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J Sci Res Med Sci. 2000 Jan;2(1):25-31.

In-vitro activity of synercid and related drugs against Streptococcus oralis isolated from septicaemia and endocarditis cases.

Journal for scientific research. Medical sciences

A M Rafay

Affiliations

  1. Department of Microbiology, College of Medicine, Sultan Qaboos University, P.O.Box: 35, Postal Code: 123, Muscat, Sultanate of Oman.

PMID: 24019702 PMCID: PMC3174699

Abstract

OBJECTIVE: The increase in resistance to gram positive organisms and seriousness of infective endocarditis, makes it necessary to look for an alternate treatment.

METHOD: In-vitro activity of synercid was compared with penicillin, amoxycillin, teicoplanin, vancomycin, clindamycin and erythromycin.

RESULT: Synercid showed minimum inhibitory concentrations (MIC) within the narrow range of 0.06 - 0.5 mg/l. MIC50 and mode values were both 0.25 mg/l. There was just two-fold difference between the MIC50 (0.25 mg/l) and the MIC90, (0.5 mg/l). Although the MICs of synercid for S. oralis were relatively high compared to penicillin, clindamycin, erythromycin and teicoplanin, the in-vitro bactericidal activity of synercid was much greater. Synercid MBC values were < 4 mg/l for most of the isolates, except for one of 16 mg/l and the other >64 mg/l. Killing curve was performed on six isolates of S. oralis from infective endocarditis, two from septicaemia patients and two from the oral flora of normal individuals.

CONCLUSION: Synercid showed superior bactericidal activity when compared to penicillin and vancomycin against all ten isolates of S. oralis tested. Synercid was bactericidal (99.9% kill) against all ten isolates of S. oralis within six hours of contact.

Keywords: amoxycillin; clindamycin; erythromycin; penicillin; streptococcus oralis; synercid; teicoplanin; vancomycin

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