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Pešut D, Raljević S, Kontić M, et al. Pulmonary Thromboembolism Following Radio-Frequency Ablation of the Atrioventricular Node in a Patient Heterozygous for the Factor V Leiden and the Mthfr C677T Mutations. Balkan J Med Genet. 2011;14(1):51-6doi: 10.2478/v10034-011-0018-z.
Pešut, D., Raljević, S., Kontić, M., Božić, D. z., Buha, I., & Stević, R. (2011). Pulmonary Thromboembolism Following Radio-Frequency Ablation of the Atrioventricular Node in a Patient Heterozygous for the Factor V Leiden and the Mthfr C677T Mutations. Balkan journal of medical genetics : BJMG, 14(1), 51-6. https://doi.org/10.2478/v10034-011-0018-z
Pešut, Dp, et al. "Pulmonary Thromboembolism Following Radio-Frequency Ablation of the Atrioventricular Node in a Patient Heterozygous for the Factor V Leiden and the Mthfr C677T Mutations." Balkan journal of medical genetics : BJMG vol. 14,1 (2011): 51-6. doi: https://doi.org/10.2478/v10034-011-0018-z
Pešut D, Raljević S, Kontić M, Božić Dz, Buha I, Stević R. Pulmonary Thromboembolism Following Radio-Frequency Ablation of the Atrioventricular Node in a Patient Heterozygous for the Factor V Leiden and the Mthfr C677T Mutations. Balkan J Med Genet. 2011 Jun;14(1):51-6. doi: 10.2478/v10034-011-0018-z. PMID: 24052703; PMCID: PMC3776686.
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Balkan J Med Genet. 2011 Jun;14(1):51-6. doi: 10.2478/v10034-011-0018-z.

Pulmonary Thromboembolism Following Radio-Frequency Ablation of the Atrioventricular Node in a Patient Heterozygous for the Factor V Leiden and the Mthfr C677T Mutations.

Balkan journal of medical genetics : BJMG

Dp Pešut, Sv Raljević, Mdj Kontić, Dz Božić, Ib Buha, Rs Stević

Affiliations

  1. School of Medicine, University of Belgrade, Internal Medicine Department, Belgrade, Serbia ; Clinical Centre of Serbia, Teaching Hospital of Lung Diseases, Research and Epidemiology Department, Belgrade, Serbia.

PMID: 24052703 PMCID: PMC3776686 DOI: 10.2478/v10034-011-0018-z

Abstract

Patients who undergo radiofrequency ablation of the atrioventricular (AV) node rarely develop acute major complications. A 41-year-old Caucasian male smoker, was admitted to the Pulmology Teaching Hospital at Belgrade, Serbia, for sharp persistent chest pain, fever and fatigue following AV node radiofrequency ablation for arrhythmia. Chest X-ray showed obtuse right costo-phrenic angle and laminar atelectasis in the right lower lung lobe. The plasma D-dimer level was elevated. A perfusion lung scan showed multiple bilateral perfusion defects and multislice computed tomography showed thrombotic mass in the right pulmonary artery. Genetic analysis revealed that he was heterozygous for the prothrombin Factor V (FV) Leiden and MTHFR C677T mutations. Therapy started with intravenous heparin, followed by warfarin. He had no other episodes over a 2-year follow-up. Lifelong oral anticoagulant therapy was recommended.

Keywords: Atrioventricular (AV) node; Factor V (FV) Leiden mutation; Radiofrequency ablation; Risk factor; Thromboembolism

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