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Vojvodić S, Ademović-Sazdanić D, Busarčević. Human leukocyte antigen-b27 and disease susceptibility in vojvodina, serbia. Balkan J Med Genet. 2012;15(2):55-60doi: 10.2478/bjmg-2013-0007.
Vojvodić, S., Ademović-Sazdanić, D., & Busarčević. (2012). Human leukocyte antigen-b27 and disease susceptibility in vojvodina, serbia. Balkan journal of medical genetics : BJMG, 15(2), 55-60. https://doi.org/10.2478/bjmg-2013-0007
Vojvodić, S, et al. "Human leukocyte antigen-b27 and disease susceptibility in vojvodina, serbia." Balkan journal of medical genetics : BJMG vol. 15,2 (2012): 55-60. doi: https://doi.org/10.2478/bjmg-2013-0007
Vojvodić S, Ademović-Sazdanić D, Busarčević. Human leukocyte antigen-b27 and disease susceptibility in vojvodina, serbia. Balkan J Med Genet. 2012 Dec;15(2):55-60. doi: 10.2478/bjmg-2013-0007. PMID: 24052732; PMCID: PMC3776663.
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Balkan J Med Genet. 2012 Dec;15(2):55-60. doi: 10.2478/bjmg-2013-0007.

Human leukocyte antigen-b27 and disease susceptibility in vojvodina, serbia.

Balkan journal of medical genetics : BJMG

S Vojvodić, D Ademović-Sazdanić, Busarčević

Affiliations

  1. Department for Laboratory Testing, Tissue Typing Compartment, Institute for Blood Transfusion of Vojvodina, Novi Sad, Serbia.

PMID: 24052732 PMCID: PMC3776663 DOI: 10.2478/bjmg-2013-0007

Abstract

There are numerous studies showing the role of human leukocyte antigens (HLAs) related with susceptibility or resistance to certain diseases. The aim of this study was to determine the association of HLA-B27 with ankylosing spondylitis (AS), polyarthralgia, lumboishialgia, acute anterior uveitis (AAU), psoriatic arthritis (PA), synovitis coxae and rheumatoid arthritis (RA) in patients from Vojvodina, Serbia. An HLA I class typing was performed by the serological immunomagnetic two-color fluorescence method using peripheral blood T lymphocytes in 97 patients and 224 healthy controls from the population of Vojvodina, Serbia. We calculated HLA-B27 frequencies, relative risk (RR), ethiologic fraction (EF), e.g., population attributive risk, when RR was greater than 1, while, preventive fraction (PF) was calculated when RR was lower than 1. This study revealed the strongest association of AS with HLAB27 antigen: RR = 25.0, while the EF was greater than 0.15, respectively. The χ(2) test showed the significant difference (p <0.05) in HLA-B27 in patients with AS in comparison to controls (χ(2) = 52.5). It was concluded that there is a positive association of HLA-B27 with AS and that HLA-B27 can serve as a marker for predisposition to diseases.

Keywords: Ankylosing spondylitis (AS); Cytotoxic T cells (CTL); Heavy chain (HC); Human leukocyte antigen(s) (HLAs); Major histocompatibility complex (MCH); Relative risk (RR); Spondyarthropathies (SpA); T cell receptors (TCR)

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