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Dillon S, Tobias JD. Ondansetron to treat pruritus due to cholestatic jaundice. J Pediatr Pharmacol Ther. 2013;18(3):241-6doi: 10.5863/1551-6776-18.3.241.
Dillon, S., & Tobias, J. D. (2013). Ondansetron to treat pruritus due to cholestatic jaundice. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 18(3), 241-6. https://doi.org/10.5863/1551-6776-18.3.241
Dillon, Sarah, and Tobias, Joseph D. "Ondansetron to treat pruritus due to cholestatic jaundice." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG vol. 18,3 (2013): 241-6. doi: https://doi.org/10.5863/1551-6776-18.3.241
Dillon S, Tobias JD. Ondansetron to treat pruritus due to cholestatic jaundice. J Pediatr Pharmacol Ther. 2013 Jul;18(3):241-6. doi: 10.5863/1551-6776-18.3.241. PMID: 24052788; PMCID: PMC3775559.
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J Pediatr Pharmacol Ther. 2013 Jul;18(3):241-6. doi: 10.5863/1551-6776-18.3.241.

Ondansetron to treat pruritus due to cholestatic jaundice.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Sarah Dillon, Joseph D Tobias

Affiliations

  1. School of Medicine, Upstate Medical University, Syracuse, New York.

PMID: 24052788 PMCID: PMC3775559 DOI: 10.5863/1551-6776-18.3.241

Abstract

Intractable itching is a symptom of cholestatic liver disease of various causes that is bothersome and difficult to manage. Although treatment of the primary cause of cholestasis is paramount in resolving the issue, given the debilitating consequences of pruritus, symptomatic treatment is frequently necessary. Although many medications including cholestyramine, rifampin, opioid antagonists (i.e., naloxone, naltrexone), phenobarbital, and antihistamines have been used to treat cholestatic-induced pruritus, none has resulted in uniform success. We report anecdotal success with the use of ondansetron to treat pruritus associated with cholestasis following prolonged intensive care unit course of a 16-year-old. The theories accounting for pruritus with cholestasis are presented, treatment options are reviewed, and the role of ondansetron in the treatment of pruritus is discussed.

Keywords: cholestatic jaundice; ondansetron; pruritus

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