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De Petris G, Caldero SG, Chen L, et al. Histopathological changes in the gastrointestinal tract due to medications: an update for the surgical pathologist (part II of II). Int J Surg Pathol. 2013;22(3):202-11doi: 10.1177/1066896913502230.
De Petris, G., Caldero, S. G., Chen, L., Xiao, S. Y., Dhungel, B. M., Spizcka, A. J., & Lam-Himlin, D. (2014). Histopathological changes in the gastrointestinal tract due to medications: an update for the surgical pathologist (part II of II). International journal of surgical pathology, 22(3), 202-11. https://doi.org/10.1177/1066896913502230
De Petris, Giovanni, et al. "Histopathological changes in the gastrointestinal tract due to medications: an update for the surgical pathologist (part II of II)." International journal of surgical pathology vol. 22,3 (2014): 202-11. doi: https://doi.org/10.1177/1066896913502230
De Petris G, Caldero SG, Chen L, Xiao SY, Dhungel BM, Spizcka AJ, Lam-Himlin D. Histopathological changes in the gastrointestinal tract due to medications: an update for the surgical pathologist (part II of II). Int J Surg Pathol. 2014 May;22(3):202-11. doi: 10.1177/1066896913502230. Epub 2013 Sep 10. PMID: 24021900.
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Int J Surg Pathol. 2014 May;22(3):202-11. doi: 10.1177/1066896913502230. Epub 2013 Sep 10.

Histopathological changes in the gastrointestinal tract due to medications: an update for the surgical pathologist (part II of II).

International journal of surgical pathology

Giovanni De Petris, Sonia Gatius Caldero, Longwen Chen, Shu-Yuan Xiao, Bal M Dhungel, Amy J Wendel Spizcka, Dora Lam-Himlin

Affiliations

  1. 1Mayo Clinic Arizona, Scottsdale, AZ, USA.

PMID: 24021900 DOI: 10.1177/1066896913502230

Abstract

In keeping with the stated goal of providing the surgical pathologist with tools to recognize abnormalities of the gastrointestinal (GI) tract due to drugs (AGIDS), in part II of this review we embark in a more organ-based description of AGIDS. Adequate space is given to the numerous adverse gastrointestinal effects of nonsteroidal anti-inflammatory drugs. Pill esophagitis, esophagitis dissecans, proton pump inhibitors' effects, diaphragm disease, and the recently described effects of drugs such as olmesartan, mycophenolate, and of compounds such as yttrium-90 are highlighted among several others. The inclusion of drug effects in the differential diagnosis of "conventional" diseases (such as gastric antral vascular ectasia, graft-versus-host disease, ischemic colitis, acute colitis, collagenous enteritis, inflammatory bowel disease) is underscored to avoid sometimes significant diagnostic pitfalls. We reiterate the message of the necessary collaboration between pathologist and clinician in the recognition of these entities to provide the best patient care.

Keywords: adverse gastrointestinal tract drug effect; diaphragm disease; mycophenolate; nonsteroidal anti-inflammatory drugs; olmesartan

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