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Zare A, Saremi A, Hajhashemi M, et al. Correlation between serum zinc levels and successful immunotherapy in recurrent spontaneous abortion patients. J Hum Reprod Sci. 2013;6(2):147-51doi: 10.4103/0974-1208.117170.
Zare, A., Saremi, A., Hajhashemi, M., Kardar, G. A., Moazzeni, S. M., Pourpak, Z., Salehian, P., Naderi, M., Safaralizadeh, R., & Nourizadeh, M. (2013). Correlation between serum zinc levels and successful immunotherapy in recurrent spontaneous abortion patients. Journal of human reproductive sciences, 6(2), 147-51. https://doi.org/10.4103/0974-1208.117170
Zare, Ahad, et al. "Correlation between serum zinc levels and successful immunotherapy in recurrent spontaneous abortion patients." Journal of human reproductive sciences vol. 6,2 (2013): 147-51. doi: https://doi.org/10.4103/0974-1208.117170
Zare A, Saremi A, Hajhashemi M, Kardar GA, Moazzeni SM, Pourpak Z, Salehian P, Naderi M, Safaralizadeh R, Nourizadeh M. Correlation between serum zinc levels and successful immunotherapy in recurrent spontaneous abortion patients. J Hum Reprod Sci. 2013 Apr;6(2):147-51. doi: 10.4103/0974-1208.117170. PMID: 24082657; PMCID: PMC3778605.
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J Hum Reprod Sci. 2013 Apr;6(2):147-51. doi: 10.4103/0974-1208.117170.

Correlation between serum zinc levels and successful immunotherapy in recurrent spontaneous abortion patients.

Journal of human reproductive sciences

Ahad Zare, Abotaleb Saremi, Marjan Hajhashemi, Gholam All Kardar, Seyed Mohammad Moazzeni, Zahra Pourpak, Pirouz Salehian, Maryam Naderi, Reza Safaralizadeh, Maryam Nourizadeh

Affiliations

  1. Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 24082657 PMCID: PMC3778605 DOI: 10.4103/0974-1208.117170

Abstract

BACKGROUND: Immunotherapy with paternal lymphocytes plays an important role in preventing recurrent spontaneous abortion (RSA) and is an effective treatment for it. This kind of treatment is performed as an immunotherapy method in several centers in the world. It attributes to the production of anti-paternal cytotoxic antibodies (APCAs) in women with RSA. Production of APCA after lymphocyte immunotherapy (LIT) in RSA patients gives them a better chance for successful pregnancy. Regarding the important effect of trace elements on the function of the immune system, we tried to investigate the correlation between serum zinc level and the success of LIT in RSA.

MATERIALS AND METHODS: Serum zinc concentration was determined in two groups of RSA patients using atomic absorption spectrophotometer systems. Group (a) that responded to the paternal lymphocytes and their cross-match test was positive, and group (b) that had no response to the paternal lymphocytes immunizations and their cross-match test was negative.

RESULTS: Serum zinc levels in group (a) patients were 74.98 ± 11.88 μg/dl, which was significantly higher than those in group (b) with the zinc concentration of 64.22 ± 9.22 μg/dl.

CONCLUSIONS: Zinc deficiency may be one of the substantial causes of negative results for LIT in RSA patients. Therefore, compensation of zinc defect before LIT can be a promising approach to improve the immune response in patients.

Keywords: Immunotherapy; recurrent spontaneous abortion; serum zinc levels

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