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Amiri FN, Basirat Z, Omidvar S, et al. Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes. J Nat Sci Biol Med. 2013;4(2):302-5doi: 10.4103/0976-9668.116977.
Amiri, F. N., Basirat, Z., Omidvar, S., Sharbatdaran, M., Tilaki, K. H., & Pouramir, M. (2013). Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes. Journal of natural science, biology, and medicine, 4(2), 302-5. https://doi.org/10.4103/0976-9668.116977
Amiri, Fatemeh Nasiri, et al. "Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes." Journal of natural science, biology, and medicine vol. 4,2 (2013): 302-5. doi: https://doi.org/10.4103/0976-9668.116977
Amiri FN, Basirat Z, Omidvar S, Sharbatdaran M, Tilaki KH, Pouramir M. Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes. J Nat Sci Biol Med. 2013 Jul;4(2):302-5. doi: 10.4103/0976-9668.116977. PMID: 24082721; PMCID: PMC3783769.
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J Nat Sci Biol Med. 2013 Jul;4(2):302-5. doi: 10.4103/0976-9668.116977.

Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes.

Journal of natural science, biology, and medicine

Fatemeh Nasiri Amiri, Zahra Basirat, Shabnam Omidvar, Majid Sharbatdaran, Karimollah Hajian Tilaki, Mahdi Pouramir

Affiliations

  1. Department of Nursing and Midwifery, Babol University of Medical Sciences, Babol, Iran.

PMID: 24082721 PMCID: PMC3783769 DOI: 10.4103/0976-9668.116977

Abstract

BACKGROUND: Gestational diabetes mellitus (GDM) is the most common metabolic disorder during pregnancy. GDM causes substantial morbidity and mortality and long- term complications. GDM-related risk factors have not been completely identified yet. Some studies have found relationship between increased serum ferritin and impaired oral glucose tolerance test but the relationship between serum ferritin and risk of GDM has been controversial. The aim of the study was to determine serum iron and ferritin levels and total iron binding capacity (TIBC) in women with GDM and comparison with normal pregnant women.

MATERIALS AND METHODS: This case-control study was performed among 200 pregnant women (case = 100, control = 100) who were referred to Yahya-Nejad Hospital in the second trimester in Babol from 2008 to 2009. GDM was diagnosed by impaired OGTT based on Carpenter and Coustan criteria. The 2 groups were matched in age, gestational age and parity.

RESULTS: High serum ferritin level increased the risk of gestational diabetes to 2.4-fold [OR = 2.4 (0.83-6.9) CI = 95% (P = 0.10)], while in those with low ferritin levels, the risk of developing gestational diabetes was reduced to 82% [OR = 0.8 with (0.08-0.37) CI = 95% (P = 0.001)]. Using the logistic regression model, after adjustment for BMI, the OR was 2.37 [(0.80-7.01) CI = 95% (P = 0.11)] for low ferritin level and OR = 0.20 [(0.09-0.44) CI = 95% (P = 0.0001)] for high ferritin level, which was statistically significant.

CONCLUSION: The serum ferritin level was markedly higher in women with gestational diabetes than in normal pregnant women; therefore, high ferritin can be regarded as a significant risk factor for the development of gestational diabetes.

Keywords: Ferritin; gestational diabetes mellitus; serum iron; total iron binding capacity

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