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Kojuri J, Ostovan MA, Rezaian GR, et al. Effect of omega-3 on brain natriuretic peptide and echocardiographic findings in heart failure: Double-blind placebo-controlled randomized trial. J Cardiovasc Dis Res. 2013;4(1):20-4doi: 10.1016/j.jcdr.2013.02.013.
Kojuri, J., Ostovan, M. A., Rezaian, G. R., Archin Dialameh, P., Zamiri, N., Sharifkazemi, M. B., & Jannati, M. (2013). Effect of omega-3 on brain natriuretic peptide and echocardiographic findings in heart failure: Double-blind placebo-controlled randomized trial. Journal of cardiovascular disease research, 4(1), 20-4. https://doi.org/10.1016/j.jcdr.2013.02.013
Kojuri, J, et al. "Effect of omega-3 on brain natriuretic peptide and echocardiographic findings in heart failure: Double-blind placebo-controlled randomized trial." Journal of cardiovascular disease research vol. 4,1 (2013): 20-4. doi: https://doi.org/10.1016/j.jcdr.2013.02.013
Kojuri J, Ostovan MA, Rezaian GR, Archin Dialameh P, Zamiri N, Sharifkazemi MB, Jannati M. Effect of omega-3 on brain natriuretic peptide and echocardiographic findings in heart failure: Double-blind placebo-controlled randomized trial. J Cardiovasc Dis Res. 2013 Mar;4(1):20-4. doi: 10.1016/j.jcdr.2013.02.013. Epub 2013 Feb 27. PMID: 24023466; PMCID: PMC3758087.
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J Cardiovasc Dis Res. 2013 Mar;4(1):20-4. doi: 10.1016/j.jcdr.2013.02.013. Epub 2013 Feb 27.

Effect of omega-3 on brain natriuretic peptide and echocardiographic findings in heart failure: Double-blind placebo-controlled randomized trial.

Journal of cardiovascular disease research

J Kojuri, M A Ostovan, G R Rezaian, P Archin Dialameh, N Zamiri, M B Sharifkazemi, M Jannati

Affiliations

  1. Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran ; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 24023466 PMCID: PMC3758087 DOI: 10.1016/j.jcdr.2013.02.013

Abstract

BACKGROUND: Possible beneficial effects of dietary omega-3 supplementation on patients with congestive heart failure (CHF) were investigated.

METHODS AND RESULTS: 100 patients with CHF who had a tri-chamber pacemaker and automated defibrillator were initially recruited, and 70 agreed to participate.38 patients received 2 g/day of omega-3 and 32 received placebo capsules. BNP level, 6-min walk test and echocardiographic parameters were recorded at baseline and after 6 months of treatment. BNP levels decreased significantly after 6 months in the omega-3 group, from 1766.2 ± 1978.1 pg/mL to 1159.4 ± 1430.9 pg/dL (P < 0.005). Tei index and late diastolic velocity index were significantly improved in treated group. Mortality and hospitalization rates did not differ.

CONCLUSION: The beneficial effects of omega-3 supplementation in patients with CHF were not as clear as hypothesized; however, omega-3 fatty acids can result in small changes in plasma BNP levels and modest improvements in echocardiographically assessed diastolic function (Clinical trial.gov registration: NCT01227837).

Keywords: Brain natriuretic peptide; Congestive; Heart failure; Omega-3

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