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Heidari MM, Foruzannia SK, Khatami M, et al. Apolipoprotein e gene polymorphism in Iranian coronary atherosclerosis patients candidate for coronary artery bypass graft. Iran J Basic Med Sci. 2013;16(7):841-4
Heidari, M. M., Foruzannia, S. K., Khatami, M., Hadadzadeh, M., & Emami Meybodi, M. (2013). Apolipoprotein e gene polymorphism in Iranian coronary atherosclerosis patients candidate for coronary artery bypass graft. Iranian journal of basic medical sciences, 16(7), 841-4.
Heidari, Mohammad Mehdi, et al. "Apolipoprotein e gene polymorphism in Iranian coronary atherosclerosis patients candidate for coronary artery bypass graft." Iranian journal of basic medical sciences vol. 16,7 (2013): 841-4.
Heidari MM, Foruzannia SK, Khatami M, Hadadzadeh M, Emami Meybodi M. Apolipoprotein e gene polymorphism in Iranian coronary atherosclerosis patients candidate for coronary artery bypass graft. Iran J Basic Med Sci. 2013 Jul;16(7):841-4. PMID: 23997914; PMCID: PMC3758055.
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Iran J Basic Med Sci. 2013 Jul;16(7):841-4.

Apolipoprotein e gene polymorphism in Iranian coronary atherosclerosis patients candidate for coronary artery bypass graft.

Iranian journal of basic medical sciences

Mohammad Mehdi Heidari, Seyed Khalil Foruzannia, Mehri Khatami, Mehdi Hadadzadeh, Mahmoud Emami Meybodi

Affiliations

  1. Department of Biology, Science School, Yazd University, Yazd, Iran.

PMID: 23997914 PMCID: PMC3758055

Abstract

UNLABELLED: Objective(s) : Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary artery disease (CAD) risk. The aim of this study was to study the association of the Apolipoprotein E genotypes with coronary artery disease in the Iranian population.

MATERIALS AND METHODS: The Apolipoprotein E genotype in DNA samples extracted from 66 CAD+ patients and 61 control subjects by restricting enzyme digestion of amplified exon 4 APOE gene was determined. Results : The ε3 allele was found at similar frequency in control subjects (88.5%) and atherosclerosis patients (83.3%) (P=0.314). Our results showed that the frequency of the ɛ3/ɛ3 and ε3/ε4 genotypes increased in three-vessel-disease patients and the frequency of ɛ2/ɛ2 genotype increased in one-vessel-disease patients. Conclusion : ɛ3/ɛ3 and ɛ3/ɛ4 genotypes are suggested to be predisposing factors, which, in combination with environmental factors, may trigger the degree of luminal narrowing. The possible mechanisms remain elusive and require further studies.

Keywords: Apolipoprotein E; Coronary Atherosclerosis; Polymorphism; Restriction Isotyping

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