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Comstock SM, Pound LD, Bishop JM, et al. High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate. Mol Metab. 2012;2(1):10-22doi: 10.1016/j.molmet.2012.11.001.
Comstock, S. M., Pound, L. D., Bishop, J. M., Takahashi, D. L., Kostrba, A. M., Smith, M. S., & Grove, K. L. (2012). High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate. Molecular metabolism, 2(1), 10-22. https://doi.org/10.1016/j.molmet.2012.11.001
Comstock, Sarah M, et al. "High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate." Molecular metabolism vol. 2,1 (2012): 10-22. doi: https://doi.org/10.1016/j.molmet.2012.11.001
Comstock SM, Pound LD, Bishop JM, Takahashi DL, Kostrba AM, Smith MS, Grove KL. High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate. Mol Metab. 2012 Nov 14;2(1):10-22. doi: 10.1016/j.molmet.2012.11.001. eCollection 2012. PMID: 24024126; PMCID: PMC3757659.
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Mol Metab. 2012 Nov 14;2(1):10-22. doi: 10.1016/j.molmet.2012.11.001. eCollection 2012.

High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate.

Molecular metabolism

Sarah M Comstock, Lynley D Pound, Jacalyn M Bishop, Diana L Takahashi, Ashley M Kostrba, M Susan Smith, Kevin L Grove

Affiliations

  1. Presently at: Corban University, 5000 Deer Park Drive SE, Salem, OR 97317.

PMID: 24024126 PMCID: PMC3757659 DOI: 10.1016/j.molmet.2012.11.001

Abstract

We investigated the impact of poor maternal nutrition and metabolic health on the development of islets of the nonhuman primate (NHP). Interestingly, fetal offspring of high fat diet (HFD) fed animals had normal total islet and β cell mass; however, there was a significant reduction in α cell mass, and decreased expression of transcription factors involved in α cell differentiation. In juvenile animals all offspring maintained on a HFD during the postweaning period demonstrated increases in total islet mass, however, the control offspring displaying increased islet number, and HFD offspring displayed increased islet size. Finally, while control offspring had increases in α and β cells, the HFD offspring had increases only in β cell number. These studies indicate that consumption of a HFD diet during pregnancy in the NHP, independent of maternal metabolic health, causes long-term abnormalities in α cell plasticity that may contribute to chronic disease susceptibility.

Keywords: CTR, Control.; Development; Diabetes; HFD, High-fat diet; High fat diet; Obesity; Pancreas; Pregnancy

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