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Canarelli JP, Richard S, Romond MB, et al. Bacterial translocation, intestinal morphology, and enzyme activities after ileal ischemia in newborn piglets. Pediatr Surg Int. 1996;11(7):453-5doi: 10.1007/BF00180081.
Canarelli, J. P., Richard, S., Romond, M. B., Plancq, M. C., Cordonnier, C., De Boissieu, D., Pepay, M., Postel, J. P., Leke, A., & Dupont, C. (1996). Bacterial translocation, intestinal morphology, and enzyme activities after ileal ischemia in newborn piglets. Pediatric surgery international, 11(7), 453-5. https://doi.org/10.1007/BF00180081
Canarelli, J P, et al. "Bacterial translocation, intestinal morphology, and enzyme activities after ileal ischemia in newborn piglets." Pediatric surgery international vol. 11,7 (1996): 453-5. doi: https://doi.org/10.1007/BF00180081
Canarelli JP, Richard S, Romond MB, Plancq MC, Cordonnier C, De Boissieu D, Pepay M, Postel JP, Leke A, Dupont C. Bacterial translocation, intestinal morphology, and enzyme activities after ileal ischemia in newborn piglets. Pediatr Surg Int. 1996 Aug;11(7):453-5. doi: 10.1007/BF00180081. PMID: 24057781.
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Pediatr Surg Int. 1996 Aug;11(7):453-5. doi: 10.1007/BF00180081.

Bacterial translocation, intestinal morphology, and enzyme activities after ileal ischemia in newborn piglets.

Pediatric surgery international

J P Canarelli, S Richard, M B Romond, M C Plancq, C Cordonnier, D De Boissieu, M Pepay, J P Postel, A Leke, C Dupont

Affiliations

  1. Department of Pediatric Surgery, Hôpital Nord, C. H. U., F-80054, Amiens Cédex 1, France.

PMID: 24057781 DOI: 10.1007/BF00180081

Abstract

Intestinal ischemia was created after a limited laparotomy by ligation of the terminal mesenteric vessels in the last 10 cm of distal ileum in 2-day-old piglets. Five groups (each n = 15) were studied: 1 (unoperated control group, killed on day 4), 2 (sham control with laparotomy, killed on day 4), 3 (ischemia, killed on day 4), 4 (ischemia, killed on day 9), and 5 (unoperated control on day 9, not killed). All animals in groups 1, 2 and 5 survived. Two animals in group 3 and 1 in group 4 died (peritonitis and distal ileal perforation). In animals killed on day 9, less weight gain was observed in group 4 compared to the unoperated controls. Macroscopically, no alteration was found at laparotomy in the animals in group 1, whereas in group 2, 1 animal showed beginning peritonitis and another some degree of peritoneal adhesions in group 3, 1 piglet had an intestinal perforation and 4 had intestinal distention above the ischemic loop. In group 4, 7 animals had dilatation of the upper loops, 4 a complete stricture, and 3 peritonitis with complete necrosis of the distal ileum. Microscopic examination revealed severe lesions of the ischemic area in groups 3 and 4 and mild lesions of the upper loop. The kidney was contaminated by translocation of gram-positive cocci in 36% of cases in group 2. Germ carriage for staphylococci was estimated at 80% in the terminal ileum of animals in group 3 versus 8.3% in group 2. In groups 3 and 4, the translocation rate was 30% in the kidney and 40% in the liver. Low disaccharidase activities were found in ischemic areas in groups 3 and 4, with no difference in activity in the upper loops.

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