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Kisiel JB, Ahlquist DA. Stool DNA testing for cancer surveillance in inflammatory bowel disease: an early view. Therap Adv Gastroenterol. 2013;6(5):371-80doi: 10.1177/1756283X13487941.
Kisiel, J. B., & Ahlquist, D. A. (2013). Stool DNA testing for cancer surveillance in inflammatory bowel disease: an early view. Therapeutic advances in gastroenterology, 6(5), 371-80. https://doi.org/10.1177/1756283X13487941
Kisiel, John B, and Ahlquist, David A. "Stool DNA testing for cancer surveillance in inflammatory bowel disease: an early view." Therapeutic advances in gastroenterology vol. 6,5 (2013): 371-80. doi: https://doi.org/10.1177/1756283X13487941
Kisiel JB, Ahlquist DA. Stool DNA testing for cancer surveillance in inflammatory bowel disease: an early view. Therap Adv Gastroenterol. 2013 Sep;6(5):371-80. doi: 10.1177/1756283X13487941. PMID: 24003338; PMCID: PMC3756632.
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Therap Adv Gastroenterol. 2013 Sep;6(5):371-80. doi: 10.1177/1756283X13487941.

Stool DNA testing for cancer surveillance in inflammatory bowel disease: an early view.

Therapeutic advances in gastroenterology

John B Kisiel, David A Ahlquist

Affiliations

  1. Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

PMID: 24003338 PMCID: PMC3756632 DOI: 10.1177/1756283X13487941

Abstract

Patients with inflammatory bowel disease (IBD) are at increased risk for colorectal cancer (CRC). Despite weak supporting evidence, important logistic barriers and high cost, colonoscopy is currently the only recommended approach to CRC surveillance in patients with IBD. As such, there is imperative to explore alternative or complementary strategies with potential to improve the efficiency and effectiveness of surveillance in IBD. Given our increasing understanding of tumorigenesis in IBD and the accompanying cascade of molecular alterations, there is a strong rationale to pursue biomarker assays for this application. Stool-based DNA testing with advanced technology has been shown to be highly discriminatory for detection of sporadic colorectal cancer and advanced precancers. In early observations, stool DNA testing also shows promise for the accurate detection of IBD-associated colorectal neoplasms. These findings raise important clinical and translational questions about how to best evaluate and develop this technology, and devise clinical algorithms that will complement colonoscopy to improve patient outcomes.

Keywords: DNA methylation; colorectal neoplasms; early detection of cancer; inflammatory bowel disease; stool DNA

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