Mol Imaging Radionucl Ther. 2013 Aug;22(2):36-41. doi: 10.4274/Mirt.08370. Epub 2013 Aug 01.
Effectiveness of Fixed Dose Radioactive Iodine (RAI) for the Treatment of Hyperthyroidism: Experience of a Teaching Hospital in South West Nigeria.
Molecular imaging and radionuclide therapy
John Enyi Ejeh M, Karounwi Omotayo Ogunjobi, John Enyi Ejeh, Kayode Solomon Adedapo, Joshua F Eniojukan
Affiliations
Affiliations
- University of Ibadan, University College Hospital, Department of Nuclear Medicine, Ibadan Nigeria.
PMID: 24003395
PMCID: PMC3759307 DOI: 10.4274/Mirt.08370
Abstract
OBJECTIVE: Using radioactive iodine (RAI) as the first line therapy for Graves' hyperthyroidism and as the treatment of choice for relapsed Graves' disease is increasing in recent times. However, there has been little consensus on the most appropriate dose to use. So this study is to determine the response of hyperthyroidism to fixed doses of 370 MBq and 555 MBq RAI therapies and determine the incidence of hypothyroidism at 6 months post therapy.
METHODS: Hyperthyroid patients' case records treated with radioiodine was retrospectively reviewed to determine the response rate of hyperthyroidism to the two fixed dose regimens. Statistical analysis was done with SPSS version 15.0 and the level of statistical significance was taken as p<0.05. Forty subjects, 6 males (15%) and 34 females (85%) received RAI therapy for Graves' hyperthyroidism, mean age was 49.4 years (range, 25-75years). The thyroid function status at 6 months post therapy was available for all subjects. 24 patients (60%) received 370 MBq while 16 patients (40%) received 555 MBq.
RESULTS: The response for fixed doses of 370 MBq and 555 MBq were similar (100%). Also, the incidence of hypothyroidism in these subjects which was 66.6% with fixed dose of 370 MBq and 62.5% with fixed dose of 555 MBq within 6 months post RAI therapy were similar.
CONCLUSION: SRAI is highly effective for the treatment of hyperthyroidism, with a cure rate of 100%. However, it has proved impossible to determine a fixed dose regimen for individual patients accurately to guarantee an euthyroid state. This is because hypothyroidism is a natural predictable sequel of RAI therapy.
CONFLICT OF INTEREST: None declared.
Keywords: Hyperthyroidism; Iodine radioisotopes; Nigeria; radioisotope therapy; treatment effectiveness
References
- Eur J Endocrinol. 2005 Oct;153(4):489-98 - PubMed
- J R Soc Med. 1985 Mar;78(3):197-202 - PubMed
- Lancet. 1986 Jun 14;1(8494):1369-72 - PubMed
- J Clin Endocrinol Metab. 2001 Aug;86(8):3611-7 - PubMed
- N Engl J Med. 1994 Jun 16;330(24):1731-8 - PubMed
- J Clin Endocrinol Metab. 1999 Apr;84(4):1229-33 - PubMed
- J Nucl Med. 1991 Mar;32(3):411-6 - PubMed
- J Clin Endocrinol Metab. 1990 Jun;70(6):1518-24 - PubMed
- Clin Endocrinol (Oxf). 1988 May;28(5):487-96 - PubMed
- J Nucl Med. 1993 Oct;34(10):1638-41 - PubMed
- Clin Endocrinol (Oxf). 1991 Jan;34(1):71-6 - PubMed
- Clin Endocrinol (Oxf). 1995 Sep;43(3):325-9 - PubMed
- N Engl J Med. 1984 Aug 16;311(7):426-32 - PubMed
- Expert Opin Pharmacother. 2005 Jun;6(6):851-61 - PubMed
- J Clin Endocrinol Metab. 1998 Feb;83(2):685-7 - PubMed
- Surg Clin North Am. 2004 Jun;84(3):833-47 - PubMed
- J R Coll Physicians Lond. 1992 Oct;26(4):348-51 - PubMed
- J Clin Endocrinol Metab. 2000 Mar;85(3):1038-42 - PubMed
- Endocrinology. 2006 Jan;147(1):9-12 - PubMed
- Eur J Endocrinol. 1999 Aug;141(2):117-21 - PubMed
- Eur J Nucl Med. 1985;11(6-7):191-3 - PubMed
- Thyroid. 1997 Jun;7(3):369-75 - PubMed
- Thyroid. 1991;1(2):129-35 - PubMed
- Ann Clin Biochem. 2006 May;43(Pt 3):173-83 - PubMed
- South Med J. 1995 Aug;88(8):831-6 - PubMed
- J Am Geriatr Soc. 1994 May;42(5):513-6 - PubMed
- Eur J Clin Invest. 1995 Mar;25(3):186-93 - PubMed
- N Engl J Med. 2005 Mar 3;352(9):905-17 - PubMed
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