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J Blood Transfus. 2012;2012:407326. doi: 10.1155/2012/407326. Epub 2011 Dec 07.

Using basic ethical principles to evaluate safety efforts in transfusion medicine.

Journal of blood transfusion

Jay P Brooks

Affiliations

  1. Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, P.O. Box 100275, Gainesville, FL 32610-0275, USA.

PMID: 24089647 PMCID: PMC3777255 DOI: 10.1155/2012/407326

Abstract

Pursuit of pharmaceutical purity of the blood in the bag has led to a shrinking donor base and a significantly more expensive product. Decisions regarding new infectious marker testing and donor deferrals have typically been made emphasizing decreasing one specific risk without considering the effect the intervention will have on the overall safety and availability of blood transfusion. Regulations have been formulated by governmental agencies with limited input from the medical community. The decision making process has lacked risk benefit analyses and has not had the robustness associated with spirited discussions. Policies made in this manner may result in certain risks being decreased but can also have adverse unintended consequences. Being guided by the ethical principles of nonmaleficence, beneficence, autonomy, and justice, we need to evaluate our actions in the context of overall blood safety rather than narrowly focusing on any one area.

References

  1. Vox Sang. 2004 Nov;87(4):280-6 - PubMed
  2. Transfus Med Rev. 2011 Oct;25(4):267-92 - PubMed
  3. Vox Sang. 2004 Jan;86(1):28-40 - PubMed
  4. Transfusion. 2001 May;41(5):691-712 - PubMed
  5. Curr Opin Hematol. 2002 Nov;9(6):521-6 - PubMed
  6. N Engl J Med. 1999 Feb 18;340(7):525-33 - PubMed
  7. Vox Sang. 2003 May;84(4):265-73 - PubMed
  8. Transfusion. 2001 Oct;41(10):1310-9 - PubMed
  9. Transfusion. 2003 Jan;43(1):25-33 - PubMed
  10. Transfusion. 2006 May;46(5):869-70; author reply 870 - PubMed
  11. Am J Clin Pathol. 2001 May;115(5):674-7 - PubMed
  12. Transfusion. 2005 Oct;45(4 Suppl):189S-205S - PubMed
  13. Transfusion. 2003 Aug;43(8 Suppl):3S-46S - PubMed
  14. JAMA. 1995 Dec 6;274(21):1677-82 - PubMed
  15. Transfusion. 1991 Jan;31(1):4-11 - PubMed
  16. Transfusion. 1997 Jan;37(1):45-51 - PubMed
  17. Am J Clin Pathol. 2001 May;115(5):666-73 - PubMed
  18. Ann Intern Med. 1997 Dec 1;127(11):966-72 - PubMed
  19. Transfusion. 2005 Oct;45(4 Suppl):159S-71S - PubMed
  20. JAMA. 1999 Feb 10;281(6):545-51 - PubMed
  21. Transfusion. 2003 Sep;43(9):1190-9 - PubMed
  22. Transfusion. 1996 Mar;36(3):222-6 - PubMed

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