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Pilau MR, Alves SH, Weiblen R, et al. Antiviral activity of the Lippia graveolens (Mexican oregano) essential oil and its main compound carvacrol against human and animal viruses. Braz J Microbiol. 2011;42(4):1616-24doi: 10.1590/S1517-838220110004000049.
Pilau, M. R., Alves, S. H., Weiblen, R., Arenhart, S., Cueto, A. P., & Lovato, L. T. (2011). Antiviral activity of the Lippia graveolens (Mexican oregano) essential oil and its main compound carvacrol against human and animal viruses. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 42(4), 1616-24. https://doi.org/10.1590/S1517-838220110004000049
Pilau, Marciele Ribas, et al. "Antiviral activity of the Lippia graveolens (Mexican oregano) essential oil and its main compound carvacrol against human and animal viruses." Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] vol. 42,4 (2011): 1616-24. doi: https://doi.org/10.1590/S1517-838220110004000049
Pilau MR, Alves SH, Weiblen R, Arenhart S, Cueto AP, Lovato LT. Antiviral activity of the Lippia graveolens (Mexican oregano) essential oil and its main compound carvacrol against human and animal viruses. Braz J Microbiol. 2011 Oct;42(4):1616-24. doi: 10.1590/S1517-838220110004000049. Epub 2011 Dec 01. PMID: 24031796; PMCID: PMC3768712.
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Braz J Microbiol. 2011 Oct;42(4):1616-24. doi: 10.1590/S1517-838220110004000049. Epub 2011 Dec 01.

Antiviral activity of the Lippia graveolens (Mexican oregano) essential oil and its main compound carvacrol against human and animal viruses.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Marciele Ribas Pilau, Sydney Hartz Alves, Rudi Weiblen, Sandra Arenhart, Ana Paula Cueto, Luciane Teresinha Lovato

Affiliations

  1. Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria , Santa Maria, RS , Brasil.

PMID: 24031796 PMCID: PMC3768712 DOI: 10.1590/S1517-838220110004000049

Abstract

Mexican oregano (Lippia graveolens) is a plant found in Mexico and Central America that is traditionally used as a medicinal herb. In the present study, we investigated the antiviral activity of the essential oil of Mexican oregano and its major component, carvacrol, against different human and animal viruses. The MTT test (3-4,5-dimethythiazol-2yl)-2,5-diphenyl tetrazolium bromide) was conducted to determine the selectivity index (SI) of the essential oil, which was equal to 13.1, 7.4, 10.8, 9.7, and 7.2 for acyclovir-resistant herpes simplex virus type 1 (ACVR-HHV-1), acyclovir-sensitive HHV-1, human respiratory syncytial virus (HRSV), bovine herpesvirus type 2 (BoHV-2), and bovine viral diarrhoea virus (BVDV), respectively. The human rotavirus (RV) and BoHV-1 and 5 were not inhibited by the essential oil. Carvacrol alone exhibited high antiviral activity against RV with a SI of 33, but it was less efficient than the oil for the other viruses. Thus, Mexican oregano oil and its main component, carvacrol, are able to inhibit different human and animal viruses in vitro. Specifically, the antiviral effects of Mexican oregano oil on ACVR-HHV-1 and HRSV and of carvacrol on RV justify more detailed studies.

Keywords: DNA virus; RNA virus; Verbenaceae; antimicrobial activity; condimental herbs

References

  1. Drug Resist Updat. 2002 Apr;5(2):88-114 - PubMed
  2. Vet Clin North Am Food Anim Pract. 2010 Mar;26(1):105-21, table of contents - PubMed
  3. Antiviral Res. 2005 Aug;67(2):107-19 - PubMed
  4. Antiviral Res. 2004 Jan;61(1):57-62 - PubMed
  5. Can J Microbiol. 2008 Nov;54(11):950-6 - PubMed
  6. J Ethnopharmacol. 2009 Dec 10;126(3):512-7 - PubMed
  7. Biol Pharm Bull. 2006 Jan;29(1):135-40 - PubMed
  8. Clin Exp Pharmacol Physiol. 2005 Oct;32(10):811-6 - PubMed
  9. J Agric Food Chem. 2004 Jun 2;52(11):3309-12 - PubMed
  10. Antiviral Res. 2000 Dec;48(3):177-85 - PubMed
  11. Antiviral Res. 2001 Jan;49(1):15-24 - PubMed
  12. Pediatr Infect Dis J. 2009 Mar;28(3 Suppl):S49 - PubMed
  13. Curr Opin Gastroenterol. 2010 Jan;26(1):26-30 - PubMed
  14. Antiviral Res. 2005 Dec;68(3):163-72 - PubMed
  15. J Clin Virol. 2003 May;27(1):14-21 - PubMed
  16. Antiviral Res. 2004 Dec;64(3):195-201 - PubMed
  17. J Ethnopharmacol. 2001 Aug;76(3):201-14 - PubMed
  18. Phytother Res. 2010 May;24(5):673-9 - PubMed
  19. J Appl Microbiol. 2003;95(3):412-27 - PubMed
  20. J Ethnopharmacol. 2003 Oct;88(2-3):181-8 - PubMed
  21. Phytomedicine. 2008 Jan;15(1-2):71-8 - PubMed
  22. J Appl Microbiol. 2001 Sep;91(3):453-62 - PubMed
  23. J Pharm Pharmacol. 2005 Nov;57(11):1371-81 - PubMed
  24. J Immunol Methods. 1983 Dec 16;65(1-2):55-63 - PubMed
  25. J Clin Virol. 2004 Jun;30(2):115-33 - PubMed
  26. Phytomedicine. 2009 Sep;16(9):882-6 - PubMed
  27. Antiviral Res. 2003 Sep;60(1):1-15 - PubMed
  28. J Nat Prod. 1992 Dec;55(12):1732-40 - PubMed
  29. Antivir Chem Chemother. 2004 May;15(3):153-9 - PubMed
  30. J Virol Methods. 1991 Jun;33(1-2):61-71 - PubMed
  31. Antiviral Res. 2001 Jun;50(3):223-8 - PubMed
  32. Curr Opin Infect Dis. 2004 Oct;17(5):461-9 - PubMed
  33. J Agric Food Chem. 2009 Mar 11;57(5):1848-53 - PubMed

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