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Fox JH, Lowry CA. Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior. Front Neurosci. 2013;7:169doi: 10.3389/fnins.2013.00169.
Fox, J. H., & Lowry, C. A. (2013). Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior. Frontiers in neuroscience, 7169. https://doi.org/10.3389/fnins.2013.00169
Fox, James H, and Lowry, Christopher A. "Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior." Frontiers in neuroscience vol. 7 (2013): 169. doi: https://doi.org/10.3389/fnins.2013.00169
Fox JH, Lowry CA. Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior. Front Neurosci. 2013 Sep 20;7:169. doi: 10.3389/fnins.2013.00169. PMID: 24065880; PMCID: PMC3778254.
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Front Neurosci. 2013 Sep 20;7:169. doi: 10.3389/fnins.2013.00169.

Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior.

Frontiers in neuroscience

James H Fox, Christopher A Lowry

Affiliations

  1. Behavioral Neuroendocrinology Laboratory, Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder Boulder, CO, USA.

PMID: 24065880 PMCID: PMC3778254 DOI: 10.3389/fnins.2013.00169

Abstract

Corticotropin-releasing factor (CRF) is a 41-amino acid neuropeptide that is involved in stress-related physiology and behavior, including control of the hypothalamic-pituitary-adrenal (HPA) axis. Members of the CRF family of neuropeptides, including urocortin 1 (UCN 1), UCN 2, and UCN 3, bind to the G protein-coupled receptors, CRF type 1 (CRF1) and CRF2 receptors. In addition, CRF binding protein (CRFBP) binds both CRF and UCN 1 and can modulate their activities. There are multiple mechanisms through which CRF-related peptides may influence emotional behavior, one of which is through altering the activity of brainstem neuromodulatory systems, including serotonergic systems. CRF and CRF-related peptides act within the dorsal raphe nucleus (DR), the major source for serotonin (5-HT) in the brain, to alter the neuronal activity of specific subsets of serotonergic neurons and to influence stress-related behavior. CRF-containing axonal fibers innervate the DR in a topographically organized manner, which may contribute to the ability of CRF to alter the activity of specific subsets of serotonergic neurons. CRF and CRF-related peptides can either increase or decrease serotonergic neuronal firing rates and serotonin release, depending on their concentrations and on the specific CRF receptor subtype(s) involved. This review aims to describe the interactions between CRF-related peptides and serotonergic systems, the consequences for stress-related behavior, and implications for vulnerability to anxiety and affective disorders.

Keywords: anxiety; corticotropin-releasing factor; dorsal raphe nucleus; emotional behavior; serotonin

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