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Puszka A, Di Sieno L, Mora AD, et al. Time-resolved diffuse optical tomography using fast-gated single-photon avalanche diodes. Biomed Opt Express. 2013;4(8):1351-65doi: 10.1364/BOE.4.001351.
Puszka, A., Di Sieno, L., Mora, A. D., Pifferi, A., Contini, D., Boso, G., Tosi, A., Hervé, L., Planat-Chrétien, A., Koenig, A., & Dinten, J. M. (2013). Time-resolved diffuse optical tomography using fast-gated single-photon avalanche diodes. Biomedical optics express, 4(8), 1351-65. https://doi.org/10.1364/BOE.4.001351
Puszka, Agathe, et al. "Time-resolved diffuse optical tomography using fast-gated single-photon avalanche diodes." Biomedical optics express vol. 4,8 (2013): 1351-65. doi: https://doi.org/10.1364/BOE.4.001351
Puszka A, Di Sieno L, Mora AD, Pifferi A, Contini D, Boso G, Tosi A, Hervé L, Planat-Chrétien A, Koenig A, Dinten JM. Time-resolved diffuse optical tomography using fast-gated single-photon avalanche diodes. Biomed Opt Express. 2013 Jul 17;4(8):1351-65. doi: 10.1364/BOE.4.001351. eCollection 2013. PMID: 24009998; PMCID: PMC3756586.
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Biomed Opt Express. 2013 Jul 17;4(8):1351-65. doi: 10.1364/BOE.4.001351. eCollection 2013.

Time-resolved diffuse optical tomography using fast-gated single-photon avalanche diodes.

Biomedical optics express

Agathe Puszka, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Davide Contini, Gianluca Boso, Alberto Tosi, Lionel Hervé, Anne Planat-Chrétien, Anne Koenig, Jean-Marc Dinten

Affiliations

  1. CEA-LETI, Minatec Campus, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.

PMID: 24009998 PMCID: PMC3756586 DOI: 10.1364/BOE.4.001351

Abstract

We present the first experimental results of reflectance Diffuse Optical Tomography (DOT) performed with a fast-gated single-photon avalanche diode (SPAD) coupled to a time-correlated single-photon counting system. The Mellin-Laplace transform was employed to process time-resolved data. We compare the performances of the SPAD operated in the gated mode vs. the non-gated mode for the detection and localization of an absorbing inclusion deeply embedded in a turbid medium for 5 and 15 mm interfiber distances. We demonstrate that, for a given acquisition time, the gated mode enables the detection and better localization of deeper absorbing inclusions than the non-gated mode. These results obtained on phantoms demonstrate the efficacy of time-resolved DOT at small interfiber distances. By achieving depth sensitivity with limited acquisition times, the gated mode increases the relevance of reflectance DOT at small interfiber distance for clinical applications.

Keywords: (030.5260) Photon counting; (170.3010) Image reconstruction techniques; (170.6920) Time-resolved imaging; (170.6960) Tomography; (170.7050) Turbid media; (230.5170) Photodiodes

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