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Esposito R, Mosca A, Pieramico V, et al. Characterization of resting state activity in MCI individuals. PeerJ. 2013;1:e135doi: 10.7717/peerj.135.
Esposito, R., Mosca, A., Pieramico, V., Cieri, F., Cera, N., & Sensi, S. L. (2013). Characterization of resting state activity in MCI individuals. PeerJ, 1e135. https://doi.org/10.7717/peerj.135
Esposito, Roberto, et al. "Characterization of resting state activity in MCI individuals." PeerJ vol. 1 (2013): e135. doi: https://doi.org/10.7717/peerj.135
Esposito R, Mosca A, Pieramico V, Cieri F, Cera N, Sensi SL. Characterization of resting state activity in MCI individuals. PeerJ. 2013 Aug 20;1:e135. doi: 10.7717/peerj.135. eCollection 2013. PMID: 24010015; PMCID: PMC3757508.
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PeerJ. 2013 Aug 20;1:e135. doi: 10.7717/peerj.135. eCollection 2013.

Characterization of resting state activity in MCI individuals.

PeerJ

Roberto Esposito, Alessandra Mosca, Valentina Pieramico, Filippo Cieri, Nicoletta Cera, Stefano L Sensi

Affiliations

  1. Department of Neuroscience and Imaging, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
  2. Molecular Neurology Unit, Center of Excellence on Aging, University "G. d'Annunzio", Chieti-Pescara, Chieti, Italy.
  3. Departments of Neurology and Pharmacology, Institute for Memory Impairments and Neurological Disorders, University of California-Irvine, Irvine, CA, USA.

PMID: 24010015 PMCID: PMC3757508 DOI: 10.7717/peerj.135

Abstract

Objectives. Aging is the major risk factor for Alzheimer Disease (AD) and Mild Cognitive Impairment (MCI). The aim of this study was to identify novel modifications of brain functional connectivity in MCI patients. MCI individuals were compared to healthy elderly subjects. Methods. We enrolled 37 subjects (age range 60-80 y.o.). Of these, 13 subjects were affected by MCI and 24 were age-matched healthy elderly control (HC). Subjects were evaluated with Mini Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and prose memory (Babcock story) tests. In addition, with functional Magnetic Resonance Imaging (fMRI), we investigated resting state network (RSN) activities. Resting state (Rs) fMRI data were analyzed by means of Independent Component Analysis (ICA). Subjects were followed-up with neuropsychological evaluations for three years. Results. Rs-fMRI of MCI subjects showed increased intrinsic connectivity in the Default Mode Network (DMN) and in the Somatomotor Network (SMN). Analysis of the DMN showed statistically significant increased activation in the posterior cingulate cortex (PCC) and left inferior parietal lobule (lIPL). During the three years follow-up, 4 MCI subjects converted to AD. The subset of MCI AD-converted patients showed increased connectivity in the right Inferior Parietal Lobule (rIPL). As for SMN activity, MCI and MCI-AD converted groups showed increased level of connectivity in correspondence of the right Supramarginal Gyrus (rSG). Conclusions. Our findings indicate alterations of DMN and SMN activity in MCI subjects, thereby providing potential imaging-based markers that can be helpful for the early diagnosis and monitoring of these patients.

Keywords: AD; Aging; Alzheimer; MCI; rs-fMRI

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