Front Oncol. 2013 Sep 23;3:250. doi: 10.3389/fonc.2013.00250.
Targeted therapy for breast cancer prevention.
Frontiers in oncology
Petra den Hollander, Michelle I Savage, Powel H Brown
Affiliations
Affiliations
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center , Houston, TX , USA.
PMID: 24069582
PMCID: PMC3780469 DOI: 10.3389/fonc.2013.00250
Abstract
With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer. Targeted drugs that inhibit the estrogen receptor (ER) or estrogen-activated pathways include the selective ER modulators (tamoxifen, raloxifene, and lasofoxifene) and aromatase inhibitors (AIs) (anastrozole, letrozole, and exemestane) have been tested in preclinical and clinical studies. Tamoxifen and raloxifene have been shown to reduce the risk of breast cancer and promising results of AIs in breast cancer trials, suggest that AIs might be even more effective in the prevention of ER-positive breast cancer. However, these agents only prevent ER-positive breast cancer. Therefore, current research is focused on identifying preventive therapies for other forms of breast cancer such as human epidermal growth factor receptor 2 (HER2)-positive and triple-negative breast cancer (TNBC, breast cancer that does express ER, progesterone receptor, or HER2). HER2-positive breast cancers are currently treated with anti-HER2 therapies including trastuzumab and lapatinib, and preclinical and clinical studies are now being conducted to test these drugs for the prevention of HER2-positive breast cancers. Several promising agents currently being tested in cancer prevention trials for the prevention of TNBC include poly(ADP-ribose) polymerase inhibitors, vitamin D, and rexinoids, both of which activate nuclear hormone receptors (the vitamin D and retinoid X receptors). This review discusses currently used breast cancer preventive drugs, and describes the progress of research striving to identify and develop more effective preventive agents for all forms of breast cancer.
Keywords: TNBC; breast; cancer; prevention; therapy
References
- Lancet Oncol. 2008 Jan;9(1):45-53 - PubMed
- Nat Rev Drug Discov. 2006 Aug;5(8):671-88 - PubMed
- Cancer. 2010 Jan 15;116(2):292-301 - PubMed
- Br J Cancer. 2002 Feb 12;86(4):540-5 - PubMed
- Cell Cycle. 2010 Jan 1;9(1):188-97 - PubMed
- J Clin Oncol. 2005 Dec 1;23(34):8606-12 - PubMed
- Cancer Epidemiol Biomarkers Prev. 2003 Feb;12(2):114-9 - PubMed
- Int J Cancer. 2007 Aug 15;121(4):856-62 - PubMed
- Cancer Res. 2002 Oct 1;62(19):5405-7 - PubMed
- JAMA. 2006 Jun 21;295(23):2727-41 - PubMed
- J Natl Cancer Inst. 2007 May 2;99(9):727-37 - PubMed
- Lancet Oncol. 2012 Feb;13(2):135-44 - PubMed
- J Natl Cancer Inst. 2009 Jan 21;101(2):107-13 - PubMed
- J Natl Cancer Inst. 2004 Dec 1;96(23):1751-61 - PubMed
- N Engl J Med. 2010 Feb 25;362(8):686-96 - PubMed
- JAMA Intern Med. 2013 Mar 11;173(5):355-61 - PubMed
- Cancer Res. 2002 Jan 1;62(1):122-8 - PubMed
- Clin Cancer Res. 2009 Oct 15;15(20):6327-40 - PubMed
- Breast Cancer Res Treat. 2010 Jan;119(2):477-84 - PubMed
- Nat Rev Cancer. 2005 May;5(5):341-54 - PubMed
- Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10393-8 - PubMed
- Cancer Causes Control. 1994 Nov;5(6):491-500 - PubMed
- Clin Cancer Res. 2004 Dec 1;10(23):8059-67 - PubMed
- Clin Cancer Res. 2011 Apr 15;17(8):2314-27 - PubMed
- Breast J. 2005 Jul-Aug;11(4):278-80 - PubMed
- Breast. 2009 Aug;18 Suppl 2:S1-11 - PubMed
- J Exp Med. 1925 Nov 30;42(6):753-77 - PubMed
- Anticancer Res. 2009 Apr;29(4):1143-50 - PubMed
- Bull Exp Biol Med. 2005 Jun;139(6):721-3 - PubMed
- Mol Carcinog. 2013 Jun;52(6):446-58 - PubMed
- Mol Cells. 2013 Mar;35(3):219-25 - PubMed
- N Engl J Med. 2006 Jul 13;355(2):125-37 - PubMed
- J Clin Oncol. 2012 Jul 20;30(21):2593-600 - PubMed
- Cancer Res. 2002 Nov 15;62(22):6376-80 - PubMed
- Cancer. 2011 Jan 1;117(1):39-47 - PubMed
- Cancer Biol Ther. 2004 Aug;3(8):772-5 - PubMed
- J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):242-5 - PubMed
- Breast Cancer (Auckl). 2013;7:7-22 - PubMed
- N Engl J Med. 2009 Jul 9;361(2):123-34 - PubMed
- J Natl Cancer Inst. 2003 Dec 17;95(24):1825-33 - PubMed
- Br J Cancer. 2008 Apr 22;98(8):1380-8 - PubMed
- Cancer Res. 2006 Jan 1;66(1):362-71 - PubMed
- Br J Cancer. 1989 Jul;60(1):126-31 - PubMed
- Breast Cancer Res Treat. 2012 Aug;135(1):261-9 - PubMed
- BMC Complement Altern Med. 2013 Jan 08;13:6 - PubMed
- J Clin Oncol. 2008 Jul 10;26(20):3426-33 - PubMed
- J Natl Cancer Inst. 1998 Sep 16;90(18):1371-88 - PubMed
- Cancer Prev Res (Phila). 2010 Jun;3(6):696-706 - PubMed
- J Natl Cancer Inst. 2005 Nov 16;97(22):1652-62 - PubMed
- Mol Cancer Ther. 2006 Jun;5(6):1452-8 - PubMed
- Cancer Causes Control. 2011 Jan;22(1):125-34 - PubMed
- Nature. 2000 Aug 17;406(6797):747-52 - PubMed
- Genes Dev. 2004 Aug 15;18(16):1926-45 - PubMed
- Breast Cancer Res. 2010;12(5):R68 - PubMed
- Cancer. 2012 May 15;118(10):2594-602 - PubMed
- Expert Rev Clin Pharmacol. 2012 Nov;5(6):701-9 - PubMed
- Cancer Prev Res (Phila). 2012 Oct;5(10):1195-202 - PubMed
- Immunotherapy. 2010 Mar;2(2):213-26 - PubMed
- Int J Cancer. 2008 Apr 15;122(8):1722-9 - PubMed
- Nature. 2005 Apr 14;434(7035):913-7 - PubMed
- Clin Cancer Res. 2009 Jan 1;15(1):226-37 - PubMed
- Lancet. 2002 Sep 14;360(9336):817-24 - PubMed
- J Natl Cancer Inst. 2008 Oct 15;100(20):1439-47 - PubMed
- Annu Rev Med. 2002;53:35-57 - PubMed
- Gastroenterology. 2006 Dec;131(6):1674-82 - PubMed
- PLoS One. 2013;8(2):e56567 - PubMed
- Am J Pathol. 2012 Jul;181(1):278-93 - PubMed
- Cell Death Differ. 2004 Dec;11 Suppl 2:S126-43 - PubMed
- J Clin Oncol. 2001 May 15;19(10):2754-63 - PubMed
- Br J Cancer. 2013 May 28;108(10):2172-7 - PubMed
- Clin Transl Oncol. 2007 Aug;9(8):484-93 - PubMed
- Cancer Res. 2006 Sep 1;66(17):8707-14 - PubMed
- Cancer Res. 2006 Dec 1;66(23):11381-8 - PubMed
- Curr Opin Genet Dev. 2010 Feb;20(1):87-90 - PubMed
- Breast Cancer Res Treat. 2010 Jan;119(1):137-44 - PubMed
- Br J Cancer. 2001 May 4;84(9):1188-92 - PubMed
- IDrugs. 2010 Sep;13(9):646-56 - PubMed
- Cancer Res. 2006 Nov 1;66(21):10269-73 - PubMed
- N Engl J Med. 2011 Jun 23;364(25):2381-91 - PubMed
- Lancet. 1998 Jul 11;352(9122):98-101 - PubMed
- Breast Cancer Res. 2008;10(6):R99 - PubMed
- Clin Breast Cancer. 2009 Feb;9(1):45-50 - PubMed
- J Natl Cancer Inst. 2005 Sep 7;97(17):1262-71 - PubMed
- Breast Cancer Res Treat. 2011 Feb;126(1):215-20 - PubMed
- Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74 - PubMed
- N Engl J Med. 2005 Mar 17;352(11):1071-80 - PubMed
- Nat Rev Cancer. 2004 May;4(5):335-48 - PubMed
- Cell Cycle. 2009 Jan 1;8(1):88-96 - PubMed
- Menopause. 2003 Jul-Aug;10(4):332-6 - PubMed
- Methods Enzymol. 2006;409:493-510 - PubMed
- J Clin Oncol. 2006 May 1;24(13):2127; author reply 2127-8 - PubMed
- JAMA. 1999 Jun 16;281(23):2189-97 - PubMed
- Recent Results Cancer Res. 2011;188:147-62 - PubMed
- N Engl J Med. 2000 Jun 29;342(26):1946-52 - PubMed
- Semin Oncol. 2010 Jun;37(3):258-81 - PubMed
- Breast Cancer Res Treat. 2012 Oct;135(3):821-30 - PubMed
- Gynecol Oncol. 2002 Jul;86(1):24-7 - PubMed
- Eur J Cancer. 2013 Jul;49(10):2284-93 - PubMed
- Recent Results Cancer Res. 2003;163:96-103; discussion 264-6 - PubMed
- Cancer Prev Res (Phila). 2011 Aug;4(8):1181-9 - PubMed
- PLoS One. 2010 Sep 10;5(9): - PubMed
- J Natl Cancer Inst. 1999 Nov 3;91(21):1847-56 - PubMed
- J Steroid Biochem Mol Biol. 2003 Oct;87(1):35-45 - PubMed
- Breast Cancer Res Treat. 2012 Feb;131(3):915-24 - PubMed
- Biochem Biophys Res Commun. 2013 Mar 1;432(1):123-8 - PubMed
- J Natl Cancer Inst. 2007 Feb 21;99(4):283-90 - PubMed
- Cancer Epidemiol Biomarkers Prev. 2002 May;11(5):467-74 - PubMed
- Lancet. 1998 Jul 11;352(9122):93-7 - PubMed
- N Engl J Med. 2012 Feb 9;366(6):520-9 - PubMed
- J Natl Cancer Inst. 2007 Feb 21;99(4):272-82 - PubMed
- Clin Breast Cancer. 2007 Dec;7(11):895-900 - PubMed
- Epidemiology. 2002 May;13(3):262-7 - PubMed
- N Engl J Med. 1990 Sep 20;323(12):795-801 - PubMed
- Cancer Res. 1979 Apr;39(4):1339-46 - PubMed
- Mol Endocrinol. 2011 Mar;25(3):516-28 - PubMed
- Cancer Prev Res (Phila). 2012 Sep;5(9):1144-54 - PubMed
- Genome Biol. 2007;8(5):R76 - PubMed
- Breast Cancer Res Treat. 2011 Aug;128(3):783-94 - PubMed
- N Engl J Med. 2006 Aug 31;355(9):885-95 - PubMed
- Lancet. 2011 Aug 27;378(9793):771-84 - PubMed
- Expert Rev Anticancer Ther. 2008 Sep;8(9):1377-85 - PubMed
- CA Cancer J Clin. 2013 Jan;63(1):11-30 - PubMed
- Cancer Prev Res (Phila). 2012 Aug;5(8):1036-43 - PubMed
- J Natl Cancer Inst. 2008 Jun 18;100(12):854-61 - PubMed
- Clin Cancer Res. 2007 Oct 15;13(20):6224-31 - PubMed
- Ann Oncol. 2006 Jul;17(7):1065-71 - PubMed
- J Clin Invest. 2011 Jul;121(7):2750-67 - PubMed
- Clin Cancer Res. 2000 Sep;6(9):3696-704 - PubMed
- Curr Oncol. 2007 Jun;14(3):89-96 - PubMed
- Lancet. 2012 Nov 17;380(9855):1778-86 - PubMed
- Lancet. 2003 Jan 25;361(9354):296-300 - PubMed
- Science. 2005 Dec 9;310(5754):1642-6 - PubMed
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