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Zhang J, Shi S. A literature review of AD7c-ntp as a biomarker for Alzheimer's disease. Ann Indian Acad Neurol. 2013;16(3):307-9doi: 10.4103/0972-2327.116902.
Zhang, J., & Shi, S. (2013). A literature review of AD7c-ntp as a biomarker for Alzheimer's disease. Annals of Indian Academy of Neurology, 16(3), 307-9. https://doi.org/10.4103/0972-2327.116902
Zhang, Jian, and Shi, Shengliang. "A literature review of AD7c-ntp as a biomarker for Alzheimer's disease." Annals of Indian Academy of Neurology vol. 16,3 (2013): 307-9. doi: https://doi.org/10.4103/0972-2327.116902
Zhang J, Shi S. A literature review of AD7c-ntp as a biomarker for Alzheimer's disease. Ann Indian Acad Neurol. 2013 Jul;16(3):307-9. doi: 10.4103/0972-2327.116902. PMID: 24101807; PMCID: PMC3788271.
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Ann Indian Acad Neurol. 2013 Jul;16(3):307-9. doi: 10.4103/0972-2327.116902.

A literature review of AD7c-ntp as a biomarker for Alzheimer's disease.

Annals of Indian Academy of Neurology

Jian Zhang, Shengliang Shi

Affiliations

  1. Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.

PMID: 24101807 PMCID: PMC3788271 DOI: 10.4103/0972-2327.116902

Abstract

The cornerstone of diagnosis of Alzheimer's disease (AD) is still the clinical criteria for probable and possible AD established by the NINCDS-ADRDA Work Group in 1984, which had survived for over 27 years. However, with the increase in people's knowledge of clinical manifestations and biology of AD, this standard is gradually proving to be insufficient; the early diagnosis of AD is thus particularly important. Therefore, in 2011, the National Institute on Aging and the Alzheimer's Association revised the criteria and integrated biomarker evidence into it. Biomarker evidence is expected to enhance the pathophysiological specificity of the diagnosis of AD. According to Consensus Report of the Working Group on Molecular and Biochemical Markers of Alzheimer's Disease, a qualified biomarker for AD should have the following abilities: It should detect a fundamental feature of neuropathology and be validated in neuropathologically confirmed cases, reliably with an sensitivity >80% for detecting AD and a specificity >80% for distinguishing other dementias; be reproducible and non-invasive; and be simple to perform and inexpensive. Alzheimer-associated neuronal thread protein (AD7c-NTP) is a member of "neuronal thread proteins" (NTPs); it can be detected in increased concentration in cortical neurons, brain-tissue extracts, cerebrospinal fluid, and urine in the early course of AD neurodegeneration, and it level is proportional to the degree of dementia, which makes it a promising biomarker for AD. In this review, we have evaluated the feasibility of developing AD7c-NTP as a biomarker for AD.

Keywords: AD7c-NTP; Alzheimer's disease; CSF; biomarker; brain tissue extracts; cortical neurons; urine

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