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Mak JC, Ho SP, Ho AS, et al. Sustained elevation of systemic oxidative stress and inflammation in exacerbation and remission of asthma. ISRN Allergy. 2013;2013:561831doi: 10.1155/2013/561831.
Mak, J. C., Ho, S. P., Ho, A. S., Law, B. K., Cheung, A. H., Ho, J. C., Ip, M. S., & Chan-Yeung, M. M. (2013). Sustained elevation of systemic oxidative stress and inflammation in exacerbation and remission of asthma. ISRN allergy, 2013561831. https://doi.org/10.1155/2013/561831
Mak, Judith C W, et al. "Sustained elevation of systemic oxidative stress and inflammation in exacerbation and remission of asthma." ISRN allergy vol. 2013 (2013): 561831. doi: https://doi.org/10.1155/2013/561831
Mak JC, Ho SP, Ho AS, Law BK, Cheung AH, Ho JC, Ip MS, Chan-Yeung MM. Sustained elevation of systemic oxidative stress and inflammation in exacerbation and remission of asthma. ISRN Allergy. 2013 Aug 29;2013:561831. doi: 10.1155/2013/561831. eCollection 2013. PMID: 24073339; PMCID: PMC3773380.
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ISRN Allergy. 2013 Aug 29;2013:561831. doi: 10.1155/2013/561831. eCollection 2013.

Sustained elevation of systemic oxidative stress and inflammation in exacerbation and remission of asthma.

ISRN allergy

Judith C W Mak, Siu P Ho, Alice S S Ho, Barbara K W Law, Amy H K Cheung, James C M Ho, Mary S M Ip, Moira M W Chan-Yeung

Affiliations

  1. Division of Respiratory Medicine, Departments of Medicine, The University of Hong Kong, Hong Kong ; Pharmacology & Pharmacy, The University of Hong Kong, Hong Kong ; Research Centre for Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Hong Kong ; Room L8-40, Laboratory Block, LKS Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Hong Kong.

PMID: 24073339 PMCID: PMC3773380 DOI: 10.1155/2013/561831

Abstract

Oxidative stress has been implicated in the pathogenesis of asthma. We aimed at investigating the biomarkers of oxidative stress, inflammation, and tissue damage in patients with asthma in acute exacerbation and remission. We recruited 18 asthmatics admitted to hospital with acute exacerbation and 18 healthy nonsmoking controls matched for age. We evaluated plasma levels of 8-isoprostane, C-reactive protein (CRP) and total matrix metalloproteinase- (MMP-) 9 by ELISA, and MMP-9 activity by zymographic analysis. Plasma levels of 8-isoprostane and CRP were significantly elevated in acute exacerbation and decreased in remission but remained significantly higher compared to healthy controls. The activities of pro-MMP-9 were also significantly higher in acute exacerbation and decreased in remission but remained significantly higher compared to healthy controls in parallel to plasma levels of total MMP-9. These data suggest that overproduction of MMP-9 along with highly elevated levels of oxidative stress and inflammation is implicated in asthma exacerbation and that measurements of these biomarkers can be a valid index in its management.

References

  1. Curr Drug Targets Inflamm Allergy. 2005 Apr;4(2):177-81 - PubMed
  2. Am J Respir Crit Care Med. 1999 Feb;159(2):596-602 - PubMed
  3. Eur Respir J. 2003 Jan;21(1):177-86 - PubMed
  4. Ann Allergy Asthma Immunol. 2007 Jul;99(1):48-53 - PubMed
  5. Hypertension. 2000 Jun;35(6):1307-13 - PubMed
  6. J Clin Invest. 2003 Jun;111(12):1805-12 - PubMed
  7. Pediatr Int. 2008 Feb;50(1):12-6 - PubMed
  8. Respiration. 2004 Mar-Apr;71(2):120-5 - PubMed
  9. Respir Med. 2009 Dec;103(12):1878-84 - PubMed
  10. Clin Exp Allergy. 2001 Oct;31(10):1623-30 - PubMed
  11. Clin Exp Allergy. 2002 Feb;32(2):217-23 - PubMed
  12. Am J Respir Crit Care Med. 2005 Mar 1;171(5):426-30 - PubMed
  13. Thorax. 2003 Jun;58(6):505-9 - PubMed
  14. Chest. 2002 Nov;122(5):1543-52 - PubMed
  15. Clin Chim Acta. 2001 Mar;305(1-2):107-14 - PubMed
  16. Clin Chim Acta. 2009 Jan;399(1-2):79-82 - PubMed
  17. Respir Med. 2009 Mar;103(3):379-85 - PubMed
  18. Lipids. 2000 Sep;35(9):967-74 - PubMed
  19. Thorax. 2003 Sep;58(9):757-60 - PubMed
  20. Eur Respir J. 2006 May;27(5):908-12 - PubMed
  21. Int Arch Allergy Immunol. 2008;146 Suppl 1:67-72 - PubMed
  22. Am J Respir Cell Mol Biol. 1997 Nov;17(5):583-91 - PubMed
  23. Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 2):S25-30 - PubMed
  24. Thorax. 2005 Jun;60(6):451-4 - PubMed
  25. Int Arch Allergy Immunol. 2000 Nov;123(3):259-67 - PubMed
  26. Am J Respir Crit Care Med. 1999 Jul;160(1):216-20 - PubMed
  27. Thorax. 2006 Oct;61(10):909-15 - PubMed
  28. Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36 - PubMed
  29. J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):356-63 - PubMed
  30. Am J Respir Cell Mol Biol. 1997 Mar;16(3):212-9 - PubMed
  31. Br J Clin Pharmacol. 1996 Jul;42(1):3-10 - PubMed
  32. Am J Respir Crit Care Med. 1998 Dec;158(6):1945-50 - PubMed

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