Display options
Cite
Tantraworasin A, Saeteng S, Lertprasertsuke N, et al. Completely resected n0 non-small cell lung cancer: prognostic factors affecting long-term survival. ISRN Surg. 2013;2013:175304doi: 10.1155/2013/175304.
Tantraworasin, A., Saeteng, S., Lertprasertsuke, N., Arayawudhikule, N., Kasemsarn, C., & Patumanond, J. (2013). Completely resected n0 non-small cell lung cancer: prognostic factors affecting long-term survival. ISRN surgery, 2013175304. https://doi.org/10.1155/2013/175304
Tantraworasin, Apichat, et al. "Completely resected n0 non-small cell lung cancer: prognostic factors affecting long-term survival." ISRN surgery vol. 2013 (2013): 175304. doi: https://doi.org/10.1155/2013/175304
Tantraworasin A, Saeteng S, Lertprasertsuke N, Arayawudhikule N, Kasemsarn C, Patumanond J. Completely resected n0 non-small cell lung cancer: prognostic factors affecting long-term survival. ISRN Surg. 2013 Aug 29;2013:175304. doi: 10.1155/2013/175304. eCollection 2013. PMID: 24073341; PMCID: PMC3773441.
Copy Download .nbib Format: NLM
Share it on

ISRN Surg. 2013 Aug 29;2013:175304. doi: 10.1155/2013/175304. eCollection 2013.

Completely resected n0 non-small cell lung cancer: prognostic factors affecting long-term survival.

ISRN surgery

Apichat Tantraworasin, Somcharoen Saeteng, Nirush Lertprasertsuke, Nuttapon Arayawudhikule, Choosak Kasemsarn, Jayanton Patumanond

Affiliations

  1. General Thoracic Unit, Department of Surgery, Faculty of Medicine, Chiang Mai University Hospital, Chiang Mai 50200, Thailand.

PMID: 24073341 PMCID: PMC3773441 DOI: 10.1155/2013/175304

Abstract

Background. Although early stage non-small cell lung cancer (NSCLC) has an excellent outcome and correlated with good long-term survival, up to 15 percent of patients still relapse postoperatively and die. This study is conducted to identify prognostic factors that may affect the long-term survival in completely resected N0 NSCLC. Methods. Medical records of 124 patients with completely resected N0 NSCLC were retrospectively reviewed. Prognostic factors affecting long-term survival were analyzed by the Kaplan-Meier method and Cox proportional hazards analysis. Results. Overall five-year survival rate was 48 percent. Multivariable analysis revealed stage of disease, tumor necrosis, tumor recurrence, brain metastasis, adrenal metastases, and skin metastases as significant prognostic factors affecting long-term survival. The hazard ratio (HR) of tumor necrosis, tumor recurrence, brain metastasis, adrenal metastases, and skin metastases was 2.0, 2.3, 7.6, 4.1, and 8.3, respectively, and all P values were less than 0.001. Conclusions. Our study shows stage of disease, tumor necrosis, tumor recurrence, brain metastasis, adrenal metastasis, and skin metastasis as the independent prognostic factors of long-term survival in pathological N0 NSCLC. Early stage NSCLC patients without nodal involvement or presented with tumor necrosis should benefit from adjuvant chemotherapy, and sites of metastasis could predict the long-term survival as described.

References

  1. Eur J Cardiothorac Surg. 2011 Sep;40(3):664-70 - PubMed
  2. Lung Cancer. 2007 Jun;56(3):341-8 - PubMed
  3. Cancer. 1988 May 15;61(10):2083-8 - PubMed
  4. J Thorac Oncol. 2011 Jan;6(1):48-54 - PubMed
  5. J Thorac Oncol. 2009 Jun;4(6):671-3 - PubMed
  6. Chest. 2011 Dec;140(6):1494-1502 - PubMed
  7. PLoS One. 2011;6(7):e22542 - PubMed
  8. Ann Thorac Surg. 2010 Mar;89(3):864-9 - PubMed
  9. Lung Cancer. 2005 Nov;50(2):227-34 - PubMed
  10. J Thorac Oncol. 2007 Sep;2(9):808-12 - PubMed
  11. Ann Thorac Surg. 2012 Jun;93(6):1813-20; discussion 1820-1 - PubMed
  12. Cancer. 1994 Feb 15;73(4):1177-83 - PubMed
  13. Am J Surg Pathol. 1994 May;18(5):431-8 - PubMed
  14. Acta Radiol. 2009 Oct;50(8):876-83 - PubMed
  15. Ann Thorac Surg. 2011 Apr;91(4):1059-65; discussion 1065 - PubMed
  16. Ann Thorac Surg. 2004 Nov;78(5):1748-53 - PubMed
  17. J Thorac Oncol. 2008 Jan;3(1):46-52 - PubMed
  18. J Thorac Cardiovasc Surg. 2008 Jan;135(1):44-9 - PubMed
  19. Ann Thorac Surg. 2004 Feb;77(2):421-5 - PubMed
  20. J Thorac Oncol. 2012 Aug;7(8):1263-70 - PubMed
  21. J Thorac Cardiovasc Surg. 2009 Feb;137(2):429-34 - PubMed
  22. J Thorac Cardiovasc Surg. 1998 Sep;116(3):407-11 - PubMed

Publication Types