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Yanovich R, Friedman E, Milgrom R, et al. Candidate gene analysis in israeli soldiers with stress fractures. J Sports Sci Med. 2012;11(1):147-55
Yanovich, R., Friedman, E., Milgrom, R., Oberman, B., Freedman, L., & Moran, D. S. (2012). Candidate gene analysis in israeli soldiers with stress fractures. Journal of sports science & medicine, 11(1), 147-55.
Yanovich, Ran, et al. "Candidate gene analysis in israeli soldiers with stress fractures." Journal of sports science & medicine vol. 11,1 (2012): 147-55.
Yanovich R, Friedman E, Milgrom R, Oberman B, Freedman L, Moran DS. Candidate gene analysis in israeli soldiers with stress fractures. J Sports Sci Med. 2012 Mar 01;11(1):147-55. eCollection 2012. PMID: 24149131; PMCID: PMC3737837.
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J Sports Sci Med. 2012 Mar 01;11(1):147-55. eCollection 2012.

Candidate gene analysis in israeli soldiers with stress fractures.

Journal of sports science & medicine

Ran Yanovich, Eitan Friedman, Roni Milgrom, Bernice Oberman, Laurence Freedman, Daniel S Moran

Affiliations

  1. Heller Institute of Medical Research.

PMID: 24149131 PMCID: PMC3737837

Abstract

To investigate the association of polymorphisms within candidate genes which we hypothesized may contribute to stress fracture predisposition, a case-control, cross- sectional study design was employed. Genotyping 268 Single Nucleotide Polymorphisms- SNPs within 17 genes in 385 Israeli young male and female recruits (182 with and 203 without stress fractures). Twenty-five polymorphisms within 9 genes (NR3C1, ANKH, VDR, ROR2, CALCR, IL6, COL1A2, CBG, and LRP4) showed statistically significant differences (p < 0.05) in the distribution between stress fracture cases and non stress fracture controls. Seventeen genetic variants were associated with an increased stress fracture risk, and eight variants with a decreased stress fracture risk. None of the SNP associations remained significant after correcting for multiple comparisons (false discovery rate- FDR). Our findings suggest that genes may be involved in stress fracture pathogenesis. Specifically, the CALCR and the VDR genes are intriguing candidates. The putative involvement of these genes in stress fracture predisposition requires analysis of more cases and controls and sequencing the relevant genomic regions, in order to define the specific gene mutations. Key pointsUnderstanding the possible contribution of genetic variants to stress fracture pathogenesis.There is a paucity of data on the involvement of polymorphisms in specific genes in active military personnel/athletes which may contribute to stress fractures development.The results from the current study should facilitate a more comprehensive look at the genetic component of stress fractures.

Keywords: Bone remodeling; SNPs; Stress fractures; genetic variance; inherited predisposition.

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