Display options
Cite
Psillas G, Daniilidis M, Gerofotis A, et al. Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype. Case Rep Otolaryngol. 2013;2013:590157doi: 10.1155/2013/590157.
Psillas, G., Daniilidis, M., Gerofotis, A., Veros, K., Vasilaki, A., Vital, I., & Markou, K. (2013). Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype. Case reports in otolaryngology, 2013590157. https://doi.org/10.1155/2013/590157
Psillas, G, et al. "Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype." Case reports in otolaryngology vol. 2013 (2013): 590157. doi: https://doi.org/10.1155/2013/590157
Psillas G, Daniilidis M, Gerofotis A, Veros K, Vasilaki A, Vital I, Markou K. Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype. Case Rep Otolaryngol. 2013;2013:590157. doi: 10.1155/2013/590157. Epub 2013 Sep 09. PMID: 24106629; PMCID: PMC3782810.
Copy Download .nbib Format: NLM
Share it on

Case Rep Otolaryngol. 2013;2013:590157. doi: 10.1155/2013/590157. Epub 2013 Sep 09.

Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype.

Case reports in otolaryngology

G Psillas, M Daniilidis, A Gerofotis, K Veros, A Vasilaki, I Vital, K Markou

Affiliations

  1. 1st Academic ENT Department, Ahepa University Hospital, Aristotle University, 54006 Thessaloniki, Greece.

PMID: 24106629 PMCID: PMC3782810 DOI: 10.1155/2013/590157

Abstract

Sudden sensorineural hearing loss may be present as a symptom in systemic autoimmune diseases or may occur as a primary disorder without another organ involvement (autoimmune inner ear disease). The diagnosis of autoimmune inner ear disease is still predicated on clinical features, and to date specific diagnostic tests are not available. We report a case of bilateral sudden hearing loss, tinnitus, intense rotatory vertigo, and nausea in a female patient in which the clinical manifestations, in addition to raised levels of circulating immune complexes, antithyroglobulin antibodies, and the presence of the HLA A1-B8-DR3 haplotype, allowed us to hypothesize an autoimmune inner ear disease. Cyclosporine-A immunosuppressive treatment in addition to steroids helped in hearing recovery that occurred progressively with normalization of the hearing function after a five-month treatment. Cyclosporine-A could be proposed as a therapeutic option in case of autoimmune inner ear disease allowing the suspension of corticosteroids that, at high dose, expose patients to potentially serious adverse events.

References

  1. Hum Immunol. 2001 Jul;62(7):705-13 - PubMed
  2. Laryngoscope. 1999 Jul;109(7 Pt 2):1-17 - PubMed
  3. Otol Neurotol. 2009 Jun;30(4):443-8 - PubMed
  4. Acta Otolaryngol. 1996 Sep;116(5):666-71 - PubMed
  5. Autoimmun Rev. 2011 Oct;10(12):756-61 - PubMed
  6. Arch Otolaryngol Head Neck Surg. 2001 Aug;127(8):945-9 - PubMed
  7. Laryngoscope. 1996 Nov;106(11):1347-50 - PubMed
  8. Curr Opin Immunol. 2004 Oct;16(5):660-7 - PubMed
  9. Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 2):S40-5 - PubMed
  10. Autoimmun Rev. 2002 Feb;1(1-2):29-35 - PubMed
  11. J Interferon Cytokine Res. 1996 Dec;16(12):983-8 - PubMed
  12. J Laryngol Otol. 1986 Jan;100(1):21-4 - PubMed
  13. Acta Otolaryngol. 2000 Sep;120(6):710-5 - PubMed
  14. Acta Otolaryngol. 2005 Dec;125(12):1277-82 - PubMed
  15. Ann Otol Rhinol Laryngol. 2002 Nov;111(11):989-97 - PubMed
  16. Acta Otolaryngol Suppl. 2002;(548):26-9 - PubMed

Publication Types