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Chiodi I, Belgiovine C, Donà F, et al. Drug treatment of cancer cell lines: a way to select for cancer stem cells?. Cancers (Basel). 2011;3(1):1111-28doi: 10.3390/cancers3011111.
Chiodi, I., Belgiovine, C., Donà, F., Scovassi, A. I., & Mondello, C. (2011). Drug treatment of cancer cell lines: a way to select for cancer stem cells?. Cancers, 3(1), 1111-28. https://doi.org/10.3390/cancers3011111
Chiodi, Ilaria, et al. "Drug treatment of cancer cell lines: a way to select for cancer stem cells?." Cancers vol. 3,1 (2011): 1111-28. doi: https://doi.org/10.3390/cancers3011111
Chiodi I, Belgiovine C, Donà F, Scovassi AI, Mondello C. Drug treatment of cancer cell lines: a way to select for cancer stem cells?. Cancers (Basel). 2011 Mar 04;3(1):1111-28. doi: 10.3390/cancers3011111. PMID: 24212655; PMCID: PMC3756405.
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Cancers (Basel). 2011 Mar 04;3(1):1111-28. doi: 10.3390/cancers3011111.

Drug treatment of cancer cell lines: a way to select for cancer stem cells?.

Cancers

Ilaria Chiodi, Cristina Belgiovine, Francesca Donà, A Ivana Scovassi, Chiara Mondello

Affiliations

  1. Institute of Molecular Genetics, CNR, via Abbiategrasso 207, 27100 Pavia, Italy. [email protected].

PMID: 24212655 PMCID: PMC3756405 DOI: 10.3390/cancers3011111

Abstract

Tumors are generally composed of different cell types. In recent years, it has been shown that in many types of cancers a subset of cells show peculiar characteristics, such as the ability to induce tumors when engrafted into host animals, self-renew and being immortal, and give rise to a differentiated progeny. These cells have been defined as cancer stem cells (CSCs) or tumor initiating cells. CSCs can be isolated both from tumor specimens and established cancer cell lines on the basis of their ability to exclude fluorescent dyes, express specific cell surface markers or grow in particular culture conditions. A key feature of CSCs is their resistance to chemotherapeutic agents, which could contribute to the remaining of residual cancer cells after therapeutic treatments. It has been shown that CSC-like cells can be isolated after drug treatment of cancer cell lines; in this review, we will describe the strategies so far applied to identify and isolate CSCs. Furthermore, we will discuss the possible use of these selected populations to investigate CSC biology and develop new anticancer drugs.

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