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Posadas I, López-Hernández B, Ceña V. Nicotinic receptors in neurodegeneration. Curr Neuropharmacol. 2013;11(3):298-314doi: 10.2174/1570159X11311030005.
Posadas, I., López-Hernández, B., & Ceña, V. (2013). Nicotinic receptors in neurodegeneration. Current neuropharmacology, 11(3), 298-314. https://doi.org/10.2174/1570159X11311030005
Posadas, Inmaculada, et al. "Nicotinic receptors in neurodegeneration." Current neuropharmacology vol. 11,3 (2013): 298-314. doi: https://doi.org/10.2174/1570159X11311030005
Posadas I, López-Hernández B, Ceña V. Nicotinic receptors in neurodegeneration. Curr Neuropharmacol. 2013 May;11(3):298-314. doi: 10.2174/1570159X11311030005. PMID: 24179465; PMCID: PMC3648781.
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Curr Neuropharmacol. 2013 May;11(3):298-314. doi: 10.2174/1570159X11311030005.

Nicotinic receptors in neurodegeneration.

Current neuropharmacology

Inmaculada Posadas, Beatriz López-Hernández, Valentín Ceña

Affiliations

  1. Unidad Asociada Neurodeath. CSIC-Universidad de Castilla-La Mancha, Departamento de Ciencias Médicas. Albacete, Spain and CIBERNED, Instituto de Salud Carlos III, Spain.

PMID: 24179465 PMCID: PMC3648781 DOI: 10.2174/1570159X11311030005

Abstract

Many studies have focused on expanding our knowledge of the structure and diversity of peripheral and central nicotinic receptors. Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop superfamily of pentameric ligand-gated ion channels, which include GABA (A and C), serotonin, and glycine receptors. Currently, 9 alpha (α2-α10) and 3 beta (β2-β4) subunits have been identified in the central nervous system (CNS), and these subunits assemble to form a variety of functional nAChRs. The pentameric combination of several alpha and beta subunits leads to a great number of nicotinic receptors that vary in their properties, including their sensitivity to nicotine, permeability to calcium and propensity to desensitize. In the CNS, nAChRs play crucial roles in modulating presynaptic, postsynaptic, and extrasynaptic signaling, and have been found to be involved in a complex range of CNS disorders including Alzheimer's disease (AD), Parkinson's disease (PD), schizophrenia, Tourette´s syndrome, anxiety, depression and epilepsy. Therefore, there is growing interest in the development of drugs that modulate nAChR functions with optimal benefits and minimal adverse effects. The present review describes the main characteristics of nAChRs in the CNS and focuses on the various compounds that have been tested and are currently in phase I and phase II trials for the treatment of neurodegenerative diseases including PD, AD and age-associated memory and mild cognitive impairment.

Keywords: Alzheimer disease; Parkinson disease; neurodegeneration; nicotinic receptors; pharmacology; subunit composition.

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