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Oncol Lett. 2013 Aug;6(2):323-328. doi: 10.3892/ol.2013.1418. Epub 2013 Jun 20.

Effect of .

Oncology letters

Akira Tomokuni, Hidetoshi Eguchi, Hiromitsu Hoshino, Dyah Laksmi Dewi, Shinpei Nishikawa, Yoshihiro Kano, Norikatsu Miyoshi, Arinobu Tojo, Seiichiro Kobayashi, Noriko Gotoh, Kunihiko Hinohara, Noemi Fusaki, Toshiyuki Saito, Hiroshi Suemizu, Hiroshi Wada, Shogo Kobayashi, Shigeru Marubashi, Masahiro Tanemura, Yuichiro Doki, Masaki Mori, Hideshi Ishii, Hiroaki Nagano

Affiliations

  1. Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871;

PMID: 24137324 PMCID: PMC3789096 DOI: 10.3892/ol.2013.1418

Abstract

Cancer is initiated by the transformation of stem cells or progenitor cells via a dedifferentiation process that leads to cancer stem cells; however, the process involves the activation of growth-promoting oncogenes and the inactivation of growth-constraining tumor suppressor genes. The introduction of defined factors, such as those encoded by

Keywords: Kras; differentiation; liver; p53; reprogramming

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