Display options
Cite
Snijders TM, Milivojevic B, Kemner C. Atypical excitation-inhibition balance in autism captured by the gamma response to contextual modulation. Neuroimage Clin. 2013;3:65-72doi: 10.1016/j.nicl.2013.06.015.
Snijders, T. M., Milivojevic, B., & Kemner, C. (2013). Atypical excitation-inhibition balance in autism captured by the gamma response to contextual modulation. NeuroImage. Clinical, 365-72. https://doi.org/10.1016/j.nicl.2013.06.015
Snijders, Tineke M, et al. "Atypical excitation-inhibition balance in autism captured by the gamma response to contextual modulation." NeuroImage. Clinical vol. 3 (2013): 65-72. doi: https://doi.org/10.1016/j.nicl.2013.06.015
Snijders TM, Milivojevic B, Kemner C. Atypical excitation-inhibition balance in autism captured by the gamma response to contextual modulation. Neuroimage Clin. 2013 Jul 02;3:65-72. doi: 10.1016/j.nicl.2013.06.015. eCollection 2013. PMID: 24179850; PMCID: PMC3791282.
Copy Download .nbib Format: NLM
Share it on

Neuroimage Clin. 2013 Jul 02;3:65-72. doi: 10.1016/j.nicl.2013.06.015. eCollection 2013.

Atypical excitation-inhibition balance in autism captured by the gamma response to contextual modulation.

NeuroImage. Clinical

Tineke M Snijders, Branka Milivojevic, Chantal Kemner

Affiliations

  1. Department of Experimental Psychology, Helmholtz Institute, Utrecht University, P.O. Box 80140, 3508 TC Utrecht, The Netherlands ; Department of Developmental Psychology, Utrecht University, P.O. Box 80140, 3508 TC Utrecht, The Netherlands ; Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands ; Radboud University Nijmegen, Centre for Language Studies, P.O. Box 9103, NL-6500 HD Nijmegen, The Netherlands.

PMID: 24179850 PMCID: PMC3791282 DOI: 10.1016/j.nicl.2013.06.015

Abstract

Atypical visual perception in people with autism spectrum disorders (ASD) is hypothesized to stem from an imbalance in excitatory and inhibitory processes in the brain. We used neuronal oscillations in the gamma frequency range (30-90 Hz), which emerge from a balanced interaction of excitation and inhibition in the brain, to assess contextual modulation processes in early visual perception. Electroencephalography was recorded in 12 high-functioning adults with ASD and 12 age- and IQ-matched control participants. Oscillations in the gamma frequency range were analyzed in response to stimuli consisting of small line-like elements. Orientation-specific contextual modulation was manipulated by parametrically increasing the amount of homogeneously oriented elements in the stimuli. The stimuli elicited a strong steady-state gamma response around the refresh-rate of 60 Hz, which was larger for controls than for participants with ASD. The amount of orientation homogeneity (contextual modulation) influenced the gamma response in control subjects, while for subjects with ASD this was not the case. The atypical steady-state gamma response to contextual modulation in subjects with ASD may capture the link between an imbalance in excitatory and inhibitory neuronal processing and atypical visual processing in ASD.

Keywords: Asperger's disorder; EEG; GABA; Gamma oscillations; Surround suppression; Visual perception

References

  1. Biol Psychiatry. 2009 Jan 1;65(1):22-30 - PubMed
  2. Trends Cogn Sci. 2006 Jun;10(6):258-64 - PubMed
  3. Neurology. 2002 Feb 12;58(3):428-32 - PubMed
  4. Int J Psychophysiol. 2000 Dec 1;38(3):315-36 - PubMed
  5. J Neurosci. 2006 Jun 28;26(26):6897-906 - PubMed
  6. Annu Rev Neurosci. 2012;35:203-25 - PubMed
  7. Annu Rev Neurosci. 2009;32:209-24 - PubMed
  8. Exp Brain Res. 2001 Apr;137(3-4):346-53 - PubMed
  9. Cerebellum. 2009 Mar;8(1):64-9 - PubMed
  10. Vision Res. 2001 Mar;41(5):571-83 - PubMed
  11. Nature. 1995 Feb 16;373(6515):612-5 - PubMed
  12. Neuroreport. 2001 Aug 28;12(12):2697-700 - PubMed
  13. J Neurophysiol. 2011 Nov;106(5):2303-13 - PubMed
  14. Ment Retard Dev Disabil Res Rev. 2004;10(4):303-17 - PubMed
  15. Neuroimage. 2008 May 1;40(4):1552-60 - PubMed
  16. J Neurosci. 2009 Dec 16;29(50):15721-6 - PubMed
  17. J Neurophysiol. 2003 Jul;90(1):415-30 - PubMed
  18. Comput Intell Neurosci. 2011;2011:156869 - PubMed
  19. Exp Brain Res. 1972;15(4):439-40 - PubMed
  20. Mol Autism. 2011 Jul 05;2:11 - PubMed
  21. Neuron. 1999 Sep;24(1):49-65, 111-25 - PubMed
  22. J Autism Dev Disord. 2008 Sep;38(8):1555-66 - PubMed
  23. Neuron. 2005 Nov 3;48(3):497-507 - PubMed
  24. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):900-5 - PubMed
  25. J Child Neurol. 2002 Jul;17(7):515-21 - PubMed
  26. J Child Neurol. 2002 Feb;17(2):142-5 - PubMed
  27. J Neurosci. 2004 Sep 22;24(38):8278-88 - PubMed
  28. J Neurophysiol. 2008 May;99(5):2656-71 - PubMed
  29. Eur J Neurosci. 2008 Aug;28(3):447-59 - PubMed
  30. J Autism Dev Disord. 2001 Apr;31(2):247-8 - PubMed
  31. Neuroimage. 2008 Jan 15;39(2):647-60 - PubMed
  32. PLoS One. 2012;7(7):e41326 - PubMed
  33. Brain. 2008 Apr;131(Pt 4):1013-24 - PubMed
  34. Neuroimage. 2008 Apr 15;40(3):1319-27 - PubMed
  35. J Neurosci. 2012 Jul 11;32(28):9563-73 - PubMed
  36. Brain. 2005 Oct;128(Pt 10):2430-41 - PubMed
  37. Int J Psychophysiol. 2009 Feb;71(2):177-83 - PubMed
  38. PLoS One. 2013;8(3):e57685 - PubMed
  39. Biol Psychiatry. 2007 Aug 1;62(3):192-7 - PubMed
  40. J Autism Dev Disord. 1989 Jun;19(2):185-212 - PubMed
  41. Neuron. 2008 May 8;58(3):429-41 - PubMed
  42. Int J Neuropsychopharmacol. 2010 May;13(4):487-97 - PubMed
  43. BMC Psychiatry. 2008 Aug 01;8:66 - PubMed
  44. Vision Res. 2009 Nov;49(22):2705-39 - PubMed
  45. J Autism Dev Disord. 2007 Sep;37(8):1493-504 - PubMed
  46. J Neurosci Methods. 2007 Aug 15;164(1):177-90 - PubMed
  47. J Autism Dev Disord. 2006 Jan;36(1):27-43 - PubMed
  48. Biol Psychiatry. 2011 Nov 1;70(9):806-11 - PubMed
  49. J Autism Dev Disord. 2009 Feb;39(2):223-30 - PubMed
  50. J Autism Dev Disord. 1994 Oct;24(5):659-85 - PubMed
  51. Exp Brain Res. 2010 Jun;203(3):629-35 - PubMed
  52. J Opt Soc Am. 1977 Nov;67(11):1475-89 - PubMed
  53. J Neurosci. 2010 Mar 10;30(10):3777-81 - PubMed
  54. Mol Psychiatry. 2013 Apr;18(4):435-42 - PubMed
  55. Ann Neurol. 2003 Jan;53(1):73-80 - PubMed
  56. Electroencephalogr Clin Neurophysiol. 1983 Apr;55(4):468-84 - PubMed
  57. J Neurosci. 2006 Apr 5;26(14):3624-5 - PubMed
  58. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8356-61 - PubMed
  59. Neuroscientist. 2003 Dec;9(6):496-507 - PubMed
  60. Med Sci Monit. 2002 Aug;8(8):PR1-6 - PubMed
  61. Int Rev Neurobiol. 2005;71:1-26 - PubMed
  62. Neurosci Biobehav Rev. 2012 Oct;36(9):2044-55 - PubMed
  63. J Physiol Paris. 2003 Jul-Nov;97(4-6):453-74 - PubMed
  64. Genes Brain Behav. 2003 Oct;2(5):255-67 - PubMed

Publication Types