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Yi JW, Kim HJ, Choi YJ, et al. Successful treatment by chemotherapy of pineal parenchymal tumor with intermediate differentiation: a case report. Cancer Res Treat. 2013;45(3):244-9doi: 10.4143/crt.2013.45.3.244.
Yi, J. W., Kim, H. J., Choi, Y. J., Seol, Y. M., Kahng, D. H., Choi, Y. Y., & Park, E. K. (2013). Successful treatment by chemotherapy of pineal parenchymal tumor with intermediate differentiation: a case report. Cancer research and treatment, 45(3), 244-9. https://doi.org/10.4143/crt.2013.45.3.244
Yi, Ji-Won, et al. "Successful treatment by chemotherapy of pineal parenchymal tumor with intermediate differentiation: a case report." Cancer research and treatment vol. 45,3 (2013): 244-9. doi: https://doi.org/10.4143/crt.2013.45.3.244
Yi JW, Kim HJ, Choi YJ, Seol YM, Kahng DH, Choi YY, Park EK. Successful treatment by chemotherapy of pineal parenchymal tumor with intermediate differentiation: a case report. Cancer Res Treat. 2013 Sep;45(3):244-9. doi: 10.4143/crt.2013.45.3.244. Epub 2013 Sep 30. PMID: 24155685; PMCID: PMC3804738.
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Cancer Res Treat. 2013 Sep;45(3):244-9. doi: 10.4143/crt.2013.45.3.244. Epub 2013 Sep 30.

Successful treatment by chemotherapy of pineal parenchymal tumor with intermediate differentiation: a case report.

Cancer research and treatment

Ji-Won Yi, Hyo-Jeong Kim, Young-Jin Choi, Young-Mi Seol, Dong-Hwahn Kahng, Yu-Yi Choi, Eun-Kyoung Park

Affiliations

  1. Department of Internal Medicine, Pusan National University Hospital, Pusan University College of Medicine, Busan, Korea.

PMID: 24155685 PMCID: PMC3804738 DOI: 10.4143/crt.2013.45.3.244

Abstract

A 37-year-old male presented with a mass measuring 2.5 cm in size in the midbrain and obstructive hydrocephalus, which had manifested as a headache and dizziness. Magnetic resonance (MR) imaging of the brain showed intermediate enhancement on T1-weighted MR imaging and a high intensity of enhancement on T2-weighted MR. Neurosurgeons performed an occipital craniotomy with partial removal of the tumor and the postoperative diagnosis was a pineal parenchymal tumor with intermediate differentiation. He had undergone irradiation with 54 Gy of radiation on 27 fractions for removal of the remaining tumor approximately one month after surgery. However, in follow-up imaging performed four months after radiotherapy, a remnant mass in the superoposterior aspect of the midbrain was found to have extended to the hypothalamus and the third ventricle. He was treated with six cycles of procarbazine, lomustine, vincristine chemotherapy. At five months since the completion of chemotherapy, the brain MR imaging showed no evidence of any remaining tumor and he no longer displayed any of his initial symptoms.

Keywords: Drug therapy; Pinealoma; Radiotherapy; Surgery

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